Evidence map›Paper›PMID 35398047›Full record

ArticleArchives of physical medicine and rehabilitation2022

Five-Year Cumulative Incidence of Axillary Web Syndrome and Comparison in Upper Extremity Movement, Function, Pain, and Lymphedema in Survivors of Breast Cancer With and Without Axillary Web Syndrome.

Linda Koehler, Amanda Day, David Hunter, Anne Blaes, Tufia Haddad, Ryan Shanley

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Archives of physical medicine and rehabilitation, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
1.4field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.

  1. Pooled it
  2. Article
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  5. Article
  6. Review
  7. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Linda KoehlerDivision of Physical Therapy, Department of Rehabilitation Medicine, University of Minnesota Medical School, Minneapolis, Minnesota; Division of Rehabilitation Science, Department of Rehabilitation Medicine, University of Minnesota Medical School, Minneapolis, Minnesota; Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota. Electronic address: koeh0139@umn.edu.
Amanda DayDivision of Physical Medicine and Rehabilitation, Department of Rehabilitation Medicine, University of Minnesota Medical School, Minneapolis, Minnesota.
David HunterRadiology, University of Minnesota, Minneapolis, Minnesota.
Anne BlaesMasonic Cancer Center, University of Minnesota, Minneapolis, Minnesota; Hematology/Oncology, University of Minnesota, Minneapolis, Minnesota.
Tufia HaddadDepartment of Oncology, Mayo Clinic, Rochester, Minnesota.
Ryan ShanleyMasonic Cancer Center, University of Minnesota, Minneapolis, Minnesota; Clinical and Translational Science Institute, Biostatistical Design and Analysis Center, University of Minnesota, Minneapolis, Minnesota, United States.
University of Minnesota · USUniversity of Minnesota Medical Center · USMayo Clinic · US

Funding

Women's CancerP30CA077598 · NCI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI Jeffrey S. Miller · 1998 to 2026
$100.4M
University of Minnesota Clinical and Translational Science Institute (UMN CTSI)UL1TR002494 · NCATS · UNIVERSITY OF MINNESOTA · PI BLAZAR, BRUCE R, WEISDORF, DANIEL J · 2018 to 2022
$34.9M
Univ of Minnesota Buidling Interdisciplinary Research Careers in Women's HealthK12HD055887 · NICHD · UNIVERSITY OF MINNESOTA · PI ALLEN, SHARON S, BERGE, JERICA M · 2007 to 2023
$8.6M
University of MN Building Interdisciplinary Research Careers in Women's HealthK12AR084223 · NIAMS · UNIVERSITY OF MINNESOTA · PI SHARON S ALLEN, Kristen Patricia Mark · 2023 to 2026
$2.2M
NCATS NIH HHS UL1 TR002494NCI NIH HHS P30 CA077598NIAMS NIH HHS K12 AR084223NICHD NIH HHS K12 HD055887
6 · The paper itself

Abstract

objectiveTo determine the cumulative incidence and natural history of axillary web syndrome (AWS) and its related postoperative risk for physical impairments in a cohort of women followed for 5 years post breast cancer surgery.

designProspective, longitudinal study.

settingAcademic health center.

participantsWomen (N=36) with and without AWS after breast cancer surgery with sentinel node biopsy or axillary lymph node dissection.

interventionsNot applicable.

main outcome measuresParticipants were assessed for AWS, shoulder goniometric flexion and abduction range of motion, function (Disability of the Arm, Shoulder, and Hand), lymphedema (bioimpedance spectroscopy, girth measures, tissue dielectric constant), and pain (visual analog scale) at 2, 4, 12, and 78 weeks and 5 years after breast cancer surgery. Analysis of variance compared range of motion, function, lymphedema, and pain in women identified with AWS with those without AWS across visits. Univariate logistic regression assessed if AWS was a risk factor for physical impairment at 5 years.

resultsThe cumulative incidence of AWS was 57%. Fifty percent (14/28) of the women who completed all study visits had signs of AWS at 5 years. Abduction active range of motion was significantly lower in women with AWS at 2 and 4 weeks post surgery. AWS was identified as a risk factor for reduced shoulder motion at 5 years. Regardless of AWS, 75% of the women experienced 1 or more upper extremity physical impairments at 5 years, which is an increase from 66% at 78 weeks in the same cohort.

conclusionsAWS is associated with reduced shoulder range of motion in the early postoperative time period, can persist for 5 years after breast cancer surgery, and increases the risk of long-term reduced shoulder range of motion. Long-term physical issues are apparent after breast cancer surgery regardless of AWS.

Indexed as

Breast NeoplasmsLymphedemaAxillaFemaleHumansIncidenceLongitudinal StudiesLymph Node ExcisionPainProspective StudiesRange of Motion, ArticularSurvivorsUpper ExtremityBreast neoplasmsIncidenceLymphedemaRehabilitation

Identifiers

PMID35398047
PMCPMC9452471
OpenAlexW4223515029

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.