Evidence map›Paper›PMID 35397754›Full record

Trial reportJournal of neurology2022

The INVEST trial: a randomised feasibility trial of psychologically informed vestibular rehabilitation versus current gold standard physiotherapy for people with Persistent Postural Perceptual Dizziness.

David Herdman, Sam Norton, Louisa Murdin, Kate Frost, Marousa Pavlou, Rona Moss-Morris

Open access · hybridAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of neurology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 4 pooled it
4.0field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 4 syntheses or guidelines pooled it, 51 citations in OpenAlex.

  1. Pooled it
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  4. Pooled it
  5. Review
  6. Treatment of Functional Neurological Disorders.Journal of clinical neurology (Seoul, Korea) · 2026
    Review
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  11. Review
  12. Article
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  15. Mental Health Education and Utilization Among Patients with Vestibular Disorders.Journal of clinical psychology in medical settings · 2025
    Article
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  17. Review
  18. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

David HerdmanHealth Psychology, Institute of Psychiatry Psychology and Neuroscience, King's College London, Guy's Hospital Campus, Great Maze Pond, London, SE1 9RT, UK.ORCID http://orcid.org/0000-0003-2122-5922
Sam NortonHealth Psychology, Institute of Psychiatry Psychology and Neuroscience, King's College London, Guy's Hospital Campus, Great Maze Pond, London, SE1 9RT, UK.ORCID http://orcid.org/0000-0003-1714-9963
Louisa MurdinGuy's and St, Thomas' NHS Foundation Trust, London, UK.ORCID http://orcid.org/0000-0002-7427-4878
Kate FrostSt George's University Hospitals NHS Foundation Trust, London, UK.
Marousa PavlouCentre of Human and Applied Physiological Sciences, King's College London, London, UK.ORCID http://orcid.org/0000-0002-5861-2865
Rona Moss-MorrisHealth Psychology, Institute of Psychiatry Psychology and Neuroscience, King's College London, Guy's Hospital Campus, Great Maze Pond, London, SE1 9RT, UK. rona.moss-morris@kcl.ac.uk.ORCID http://orcid.org/0000-0002-2927-3446
Guy's Hospital · GBGuy's and St Thomas' NHS Foundation Trust · GBKing's College London · GBSt George’s University Hospitals NHS Foundation Trust · GB

Funding

National Institute for Health Research ICA-CDRF-2015-01-079
6 · The paper itself

Abstract

backgroundPersistent postural perceptual dizziness (PPPD) is a common and disabling functional neuro-vestibular disorder. We aimed to determine the feasibility and acceptability of conducting a randomised controlled trial of cognitive-behavioural therapy informed vestibular rehabilitation (INVEST intervention) designed for persistent dizziness.

methodsA two-armed parallel groups randomised feasibility study of INVEST vs. a time-matched gold standard vestibular rehabilitation (VRT) control. Participants with PPPD were recruited from a specialist vestibular clinic in London, UK. Participants were individually randomised using a minimisation procedure with allocation concealment. Measures of feasibility and clinical outcome were collected and assessed at 4 months.

resultsForty adults with PPPD were randomised to six sessions of INVEST (n = 20) or gold standard VRT (n = 20). Overall, 59% of patients screened met the inclusion criteria, of which 80% enrolled. Acceptability of INVEST, as assessed against the theoretical framework of acceptability (TFA), was excellent and 80% adhered to all 6 sessions. There were small to moderate treatment effects in favour of INVEST across all measures, including dizziness handicap, negative illness perceptions, symptom focussing, fear avoidance, and distress (standardised mean difference [SMD]

conclusionsThe study results give strong support for the feasibility of a full-scale trial. Both arms had high rates of recruitment, retention, and acceptability. There was promising support of the benefits of integrated cognitive-behavioural therapy-based vestibular rehabilitation compared to gold standard vestibular rehabilitation. The study fulfilled all the a-priori criteria to advance to a full-scale efficacy trial. TRIAL REGISTRATION NUMBER: ISRCTN10420559.

Indexed as

DizzinessVestibule, LabyrinthAdultFeasibility StudiesHumansPhysical Therapy ModalitiesVertigoCognitive behavioral therapyDizzinessFeasibilityPPPDVestibularVestibular rehabilitation

Identifiers

PMID35397754
PMCPMC8994825
OpenAlexW4223426503

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.