ArticleAnnals of surgical oncology2022
Prognostic Impact of Number of Organ Invasions in Patients with Surgically Resected Thymoma.
Article in Annals of surgical oncology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 6 citations in OpenAlex.
- Narrative review: locally advanced thymoma-do we really need induction therapy before extended resection?Mediastinum (Hong Kong, China) · 2026Review
- Classification of mediastinal compartments: is separation of the superior mediastinum crucial?-a clinical practice review.Mediastinum (Hong Kong, China) · 2026Review
- Thymic tumors: radiotherapy experience for single institute.Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2025Article
- Clinical Evaluation of T Component in the Ninth Edition TNM Classification of Thymic Epithelial Tumors.Thoracic cancer · 2025Article
- The role of calcification in predicting invasion of thymoma to adjacent organs.Surgery today · 2024Article
- The Prognostic Role of the Number of Involved Structures in Thymic Epithelial Tumors: Results from the ESTS Database.Annals of surgical oncology · 2024Article
- Survival in Thymic Epithelial Tumors: The Size Matters-Comment on "Prognostic Impact of Number of Organ Invasions in Patients with Surgically Resected Thymoma".Annals of surgical oncology · 2023Article
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8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThis study aimed to explore the clinical implications and prognostic value of the number of organ/structure invasions (NOI) in patients with thymoma after curative surgical resection.
methodsWe retrospectively analyzed 306 consecutive Japanese patients with thymoma who underwent curative surgical resection. Tumor invasions of pericardium, mediastinal pleura, phrenic nerve, lung, and venous structures were examined histopathologically. Cases were classified into four subgroups according to NOI: group 0, no tumor invasion; group 1, tumor invasion into single organ/structure; group 2, tumor invasion of two organs/structures; group 3, invasion of three or more organs/structures. Associations with NOI and several clinical characteristics and their prognostic significance were analyzed.
resultsPleural invasion was found in 100 cases (32.7%), lung invasion in 48 cases (15.7%), pericardial invasion in 46 cases (15%), phrenic nerve invasion in 29 (9.5%), and venous invasion in 22 cases (7.2%). NOI was classed as group 0 in 201 cases (65.0%), group 1 in 42 cases (13.7%), group 2 in 20 cases (6.5%), and group 3 in 43 cases (14.1%). Cases with higher NOI showed significantly worse relapse-free survival (RFS) and overall survival (OS). Cox's proportional hazard model analysis also identified NOI as a prognostic factor affecting RFS and OS.
conclusionsCases with higher NOI of thymoma after radical surgical resection showed significantly worse recurrence rates and survival.
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