Evidence map›Paper›PMID 35397686›Full record

ArticleCellular and molecular life sciences : CMLS2022

Rapid shear stress-dependent ENaC membrane insertion is mediated by the endothelial glycocalyx and the mineralocorticoid receptor.

Zülfü C Cosgun, Magdalena Sternak, Benedikt Fels, Anna Bar, Grzegorz Kwiatkowski, Marta Z Pacia, Lisbeth Herrnböck, Martina Lindemann, Johannes Stegbauer, Sascha Höges and 2 more

Open access · hybridAbstract read
In one paragraph

Article in Cellular and molecular life sciences : CMLS, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 19 citations in OpenAlex.

  1. Vascular mechanical forces and vascular diseases.Journal of advanced research · 2026
    Review
  2. Article
  3. SECS, drugs, and Rac1&Rho: regulation of EnNaC in vascular endothelial cells.Pflugers Archiv : European journal of physiology · 2025
    Article
  4. Article
  5. Integrating molecular and cellular components of endothelial shear stress mechanotransduction.American journal of physiology. Heart and circulatory physiology · 2024
    Review
  6. Article
  7. Mechanosensing by Vascular Endothelium.Annual review of physiology · 2024
    Review
  8. Mechanosensory entities and functionality of endothelial cells.Frontiers in cell and developmental biology · 2024
    Review
  9. Neuraminidase inhibition improves endothelial function in diabetic mice.American journal of physiology. Heart and circulatory physiology · 2023
    Article
  10. Article
  11. Vascular mechanotransduction.Physiological reviews · 2023
    Review
  12. Review
  13. Differentiated mouse kidney tubuloids as a novelFrontiers in cell and developmental biology · 2023
    Article
  14. AFM-based nanoindentation indicates an impaired cortical stiffness in the AAV-PCSK9Pflugers Archiv : European journal of physiology · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 2 countries.

Zülfü C Cosgun *Institute of Physiology II, University of Münster, 48149, Münster, Germany.
Magdalena Sternak *Jagiellonian Centre for Experimental Therapeutics (JCET), Jagiellonian University, 30-348, Krakow, Poland.
Benedikt FelsInstitute of Physiology, University of Luebeck, 23562, Lübeck, Germany.
Anna BarJagiellonian Centre for Experimental Therapeutics (JCET), Jagiellonian University, 30-348, Krakow, Poland.
Grzegorz KwiatkowskiJagiellonian Centre for Experimental Therapeutics (JCET), Jagiellonian University, 30-348, Krakow, Poland.
Marta Z PaciaJagiellonian Centre for Experimental Therapeutics (JCET), Jagiellonian University, 30-348, Krakow, Poland.
Lisbeth HerrnböckInstitute of Physiology II, University of Münster, 48149, Münster, Germany.
Martina LindemannInstitute of Physiology II, University of Münster, 48149, Münster, Germany.
Johannes StegbauerDepartment of Nephrology, Medical Faculty, University Hospital Düsseldorf, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany.
Sascha HögesDepartment of Nephrology, Medical Faculty, University Hospital Düsseldorf, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany.
Stefan ChlopickiJagiellonian Centre for Experimental Therapeutics (JCET), Jagiellonian University, 30-348, Krakow, Poland. stefan.chlopicki@jcet.eu.
Kristina Kusche-VihrogInstitute of Physiology, University of Luebeck, 23562, Lübeck, Germany. kristina.kuschevihrog@uni-luebeck.de.ORCID http://orcid.org/0000-0002-3831-1440
Jagiellonian University · PLUniversity of Münster · DEDüsseldorf University Hospital · DEInstitute for Integrative and Experimental Genomics · DEUniversity of Lübeck · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The contribution of the shear stress-sensitive epithelial Na

Indexed as

Epithelial Sodium ChannelsGlycocalyxReceptors, MineralocorticoidStress, MechanicalAcetylcholineAnimalsCells, CulturedEndothelium, VascularHumansHuman Umbilical Vein Endothelial CellsMechanotransduction, CellularMiceMice, Inbred C57BLMice, Knockout, ApoEAcetylcholineEpithelial Sodium ChannelsReceptors, MineralocorticoidENaCEndothelial dysfunctionGlycocalyxMineralocorticoid receptorShear stress

Identifiers

PMID35397686
PMCPMC8995297
OpenAlexW4225570390

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.