ArticleScientific reports2022
Dental tissue remineralization by bioactive calcium phosphate nanoparticles formulations.
Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 43 citations in OpenAlex.
- Effects of desensitizing treatments on acid-etched dentin: debris precipitation, bond strength and tag formation.Odontology · 2026Article
- Nano-warfare in the oral cavity: antimicrobial strategies and mechanisms in nanodentistry.Odontology · 2026Review
- Bioactive Fillers in Bulk-Fill Composite Resins: A Comprehensive Review of the Effects on Polymerization Shrinkage Behavior and Mechanical Performance.Materials (Basel, Switzerland) · 2026Review
- Article
- Preliminary in-vitro antibacterial evaluation of a novel formula of calcium phosphate nanoparticle-chlorhexidine intracanal medicament using confocal laser scanning microscopy.BMC oral health · 2026Article
- Fish bone and chitosan based nanogels in green dentistry: sustainable and eco-friendly biomimetic remineralizing agents for early enamel caries.BMC oral health · 2026Article
- Effect of Ozone on Adhesion of Pediatric Bioactive Restorative MaterialsActa stomatologica Croatica · 2026Article
- More than a trend: the rationale for using bioactive materials in clinical practice.Brazilian oral research · 2026Review
- Advances in Bioactive Dental Adhesives for Caries Prevention: A State-of-the-Art Review.Journal of functional biomaterials · 2025Review
- Surface Micromorphology of Experimental Composites Doped with Bioactive Glass After Different Storage Times.Journal of functional biomaterials · 2025Article
- Antimicrobial, remineralization, and infiltration: advanced strategies for interrupting dental caries.Medical review (2021) · 2025Review
- Occlusion of Dentinal Tubules by Nanohydroxyapatite and Zinc Carbonate Hydroxyapatite-Based Toothpastes as Desensitizing Agents: An in Vitro Study.Frontiers in dentistry · 2025Article
- Advancements in nanohydroxyapatite: synthesis, biomedical applications and composite developments.Regenerative biomaterials · 2025Review
- Effect of a 1.1% NaF toothpaste containing Sr/F-doped bioactive glass on irradiated demineralized dentin: an in vitro study.BMC oral health · 2024Article
- Energy-dispersive Laue diffraction analysis of the influence of statherin and histatin on the crystallographic texture during human dental enamel demineralization.Journal of applied crystallography · 2024Article
- Dental Applications of Ion-Substituted Hydroxyapatite: A Review of the Literature.Dentistry journal · 2024Review
- Advances in hybridized nanoarchitectures for improved oro-dental health.Journal of nanobiotechnology · 2024Review
- Efficacy of F-ACP-Containing Dental Mousse in the Remineralization of White Spot Lesions after Fixed Orthodontic Therapy: A Randomized Clinical Trial.Biomedicines · 2024Article
- Bioactive ceramic-based materials: beneficial properties and potential applications in dental repair and regeneration.Regenerative medicine · 2024Review
- Enzymatically Driven Mineralization of a Calcium-Polyphosphate Bleaching Gel.Bioengineering (Basel, Switzerland) · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recent health care products are based on formulations claimed to provide enamel remineralization and dentinal tubules occlusion through calcium-phosphate bioactive nanocompounds (ion-doped hydroxyapatite and precursor, amorphous calcium phosphate nanoparticles). This study aimed to characterize, test, and compare for the first time the structure and performance of a representative, market-available sample of remineralizing toothpastes and topical mousses. Formulations were characterized to determine their composition and investigate the presence of bioactive compounds and doping elements. A conventional fluoride-containing toothpaste was used as reference. The enamel remineralization and efficacy of dentinal tubules occlusion by tested formulations were investigated ex vivo on human hard tissues. All formulations containing Ca-P bioactive nanocompounds showed remineralizing ability by epitaxial growth of a layer showing the morphology and composition of human hydroxyapatite. Such layers also embedded nanosilica clusters. The presence of doping elements or casein phosphopeptide seemed essential to allow such performances, especially when hydroxyapatite and amorphous calcium phosphate compounds were doped with small amounts of CO
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.