ArticleMicrobial cell factories2022
AdpA, a developmental regulator, promotes ε-poly-L-lysine biosynthesis in Streptomyces albulus.
Article in Microbial cell factories, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 19 citations in OpenAlex.
- Bioconversion of agricultural waste to ε-poly-L-lysine by an engineered Streptomyces albulus strain.World journal of microbiology & biotechnology · 2026Article
- Beyond Clavulanic Acid biosynthesis: Exploring the broad regulatory impact of BldD in Streptomyces clavuligerus ATCC 27064.PloS one · 2026Article
- A novel self-assembled nanocarrier-mediated dsRNA fungicide for broad-spectrum management ofMaterials today. Bio · 2025Article
- Genomic and Metabolomic Analyses ofMicroorganisms · 2025Article
- Enhanced ε-Poly-L-Lysine Production inBiomolecules · 2024Article
- Transcriptional regulators of secondary metabolite biosynthesis in Streptomyces.World journal of microbiology & biotechnology · 2024Review
- Engineering Streptomyces albulus to enhance ε-poly-L-lysine production by introducing a polyphosphate kinase-mediated ATP regeneration system.Microbial cell factories · 2023Article
- The Pleiotropic Regulator AdpA Regulates the Removal of Excessive Sulfane Sulfur inAntioxidants (Basel, Switzerland) · 2023Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
backgroundAdpA is a global regulator of morphological differentiation and secondary metabolism in Streptomyces, but the regulatory roles of the Streptomyces AdpA family on the biosynthesis of the natural product ε-poly-L-lysine (ε-PL) remain unidentified, and few studies have focused on increasing the production of ε-PL by manipulating transcription factors in Streptomyces.
resultsIn this study, we revealed the regulatory roles of different AdpA homologs in ε-PL biosynthesis and morphological differentiation and effectively promoted ε-PL production and sporulation in Streptomyces albulus NK660 by heterologously expressing adpA from S. neyagawaensis NRRLB-3092 (adpA
conclusionsHere, we characterized the positive regulatory roles of Streptomyces AdpA homologs in ε-PL biosynthesis and their effects on morphological differentiation and reported for the first time that AdpA
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