ArticleBMC oral health2022
Assessment of risk factors and molecular biomarkers in children with supernumerary teeth: a single-center study.
Article in BMC oral health, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 18 citations in OpenAlex.
- Factors associated with single versus multiple supernumerary teeth in a paediatric population: a cross-sectional study.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2026Article
- A Signaling-Threshold Framework for Human Tooth Agenesis: Integrating Molecular Genetics with Developmental Field Theory.International journal of molecular sciences · 2026Review
- Characteristics of premaxillary supernumerary teeth in non-syndromic Chinese children.BMC oral health · 2026Article
- Cone-beam CT-based age-specific risk prediction model for maxillary anterior supernumerary teeth.Scientific reports · 2026Article
- Case Report: Minimally invasive removal of impacted supernumerary teeth using digital 3D-printed surgical guides: a case series.Frontiers in surgery · 2025Article
- A Narrative Review of the Association between Dental Abnormalities and Chemotherapy.Journal of clinical medicine · 2024Review
- Extraction of an ectopic supernumerary tooth through nasal cavity with piezosurgery under local anesthesia: A case report.Clinical case reports · 2024Article
- Review
- Tooth number abnormality: from bench to bedside.International journal of oral science · 2023Review
- Article
- Nasopalatine Duct Cyst with Impacted Inverted Mesiodens: A Rare Case Report and Literature Review.Case reports in dentistry · 2022Article
- Orthodontic-Surgical Management of Triple Impacted Mesiodens and Maxillary Incisors - A Case Report.Annals of maxillofacial surgeryArticle
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSupernumerary teeth are considered one of the commonly observed dental anomalies in children. Several theories have been proposed to explain the presence of supernumerary teeth, including environmental and genetic factors. This study aimed to identify the different risk factors and molecular biomarkers in patients presented with supernumerary teeth.
methodsThis case-control study included 240 children, 6 to 12-year-old. They were divided into a test group (n = 120 children presented with supernumerary teeth) and a control group (n = 120 children with no supernumerary teeth). Questionnaires were distributed to assess demographics and exposure to several environmental factors. Ten extracted supernumerary teeth from the test group were processed for histopathological analysis.
resultsMale gender, dental history of severe oral infection or medical history of chemotherapy treatment, previous history of taking medication or illness during pregnancy, family history of neoplastic disorders, use of electronic devices, and living beside agricultural fields or industrial areas were found to be statistically significant associated with the risk of supernumerary teeth development. Immunohistochemistry panel revealed that supernumerary teeth showed enhanced expression of wingless (Wnt) and sonic hedgehog (SHH) proteins as well as a reduced expression of adenomatous polyposis coli (APC) protein, denoting molecular derangement in a group of pathways classically believed to be involved in its pathogenesis.
conclusionsMales were more frequently affected by supernumerary teeth than females. Several risk factors were notably correlated with the existence of supernumerary teeth. Additionally, molecular biomarkers assessment demonstrated a high expression level of pro-tumorigenic proteins such as Wnt and SHH in patients with supernumerary teeth.
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