ArticleBMC cancer2022
Association between age at initial diagnosis and post-metastasis mortality among women with recurrent metastatic breast cancer in China.
Article in BMC cancer, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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11 citing papers in PubMed, 20 citations in OpenAlex.
- Identification and functional analysis of exonic SNPs in MMP2 and MMP3 genes as prognostic biomarkers for breast cancer patients.Molecular genetics and genomics : MGG · 2026Article
- The association between young age at metastatic breast cancer diagnosis and overall survival in the EMBRACE study.NPJ breast cancer · 2025Article
- Multidisciplinary Team Intervention: Catalysts for Changing Prognosis in Advanced Breast Cancer.Journal of breast cancer · 2025Article
- Analysis of survival differences in advanced triple-negative breast cancer: a real-world study.Frontiers in oncology · 2025Article
- Prognostic significance of ER-to-PR difference in ER+/HER2- early breast cancer.Scientific reports · 2024Article
- Understanding cardiac events in breast cancer (UCARE): pilot cardio-oncology assessment and surveillance pathway for breast cancer patients.Breast cancer research and treatment · 2024Article
- Effect and mechanism of paclitaxel loaded on magnetic FeDrug delivery · 2023Article
- G-protein-coupled receptor 141 mediates breast cancer proliferation and metastasis by regulating oncogenic mediators and the p-mTOR/p53 axis.Oncotarget · 2023Article
- Review
- Age has a U-shaped relationship with breast cancer outcomes in women: a cohort study.Frontiers in oncology · 2023Article
- HMGA1 As a Potential Prognostic and Therapeutic Biomarker in Breast Cancer.Disease markers · 2022Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundLittle is known about whether age at initial diagnosis influences the prognosis of recurrent metastatic breast cancer (rMBC). Here, we analyzed the association between age at initial diagnosis and rMBC mortality in China.
methodsA total of 1636 women diagnosed with rMBC between 1989 and 2020 at West China Hospital, Sichuan University were included in this study. The age at initial diagnosis was categorized as young (≤ 40 years), middle-aged (41-64 years) and elderly (≥ 65 years). Post-metastasis mortality was the primary outcome and its associated factors were analyzed by Cox proportional hazards models.
resultsDuring a median follow-up of 5.2 years after initial diagnosis of breast cancer, 620 deaths were identified. Compared with middle-aged patients, elderly patients had a 70% increased risk of post-metastasis mortality (95%CI, 1.24-2.33) after adjusting for demographics, tumor characteristics and treatment modes. Similarly, elderly patients were associated with a 75% increased risk of post-metastasis mortality (95%CI, 1.19-2.59) compared with young patients. Subgroup analyses also showed similar trends.
conclusionOur findings suggest that in breast cancer, elderly patients at initial diagnosis face a higher risk of post-metastasis mortality.
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