Evidence map›Paper›PMID 35397430›Full record

ArticleBioorganic chemistry2022

Synthesis and characterization of a new Positron emission tomography probe for orexin 2 receptors neuroimaging.

Ping Bai, Yan Liu, Yulong Xu, Robin Striar, Gengyang Yuan, Sepideh Afshar, Amelia G Langan, Anna K Rattray, Changning Wang

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioorganic chemistry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 16 citations in OpenAlex.

  1. Development of NovelACS pharmacology & translational science · 2025
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  3. Emerging and upcoming therapies in insomnia.Translational and clinical pharmacology · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Ping BaiAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, United States.
Yan LiuAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, United States.
Yulong XuAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, United States.
Robin StriarAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, United States.
Gengyang YuanGordon Center for Medical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, United States.
Sepideh AfsharGordon Center for Medical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, United States.
Amelia G LanganAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, United States.
Anna K RattrayAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, United States.
Changning WangAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, United States. Electronic address: cwang15@mgh.harvard.edu.
Harvard University · US

Funding

Project 4P41EB015896 · NIBIB · MASSACHUSETTS GENERAL HOSPITAL · PI ROSEN, BRUCE R · 2012 to 2018
$9.8M
Combined MRI/PET Imager for Simultaneous Acquisition of PET/MRI DataS10RR022976 · NCRR · MASSACHUSETTS GENERAL HOSPITAL · PI JENKINS, BRUCE · 2007 to 2007
$2.0M
A Storage Area Network for Structural and Functional Image AnalysisS10RR023401 · NCRR · MASSACHUSETTS GENERAL HOSPITAL · PI FISCHL, BRUCE · 2009 to 2009
$2.0M
Electronics Upgrade for 11.7 TS10OD025234 · OD · MASSACHUSETTS GENERAL HOSPITAL · PI CARAVAN, PETER D · 2018 to 2018
$595k
Carbon-11 Automation Equipment for Human PET Radiotracer ProductionS10OD023517 · OD · MASSACHUSETTS GENERAL HOSPITAL · PI HOOKER, JACOB M. · 2018 to 2018
$502k
CYCLOTRON &RADIOCHEMISTRY: SUBSTANCE ABUSE, COCAINE, OPIOIDS10RR017208 · NCRR · MASSACHUSETTS GENERAL HOSPITAL · PI ROSEN, BRUCE R · 2004 to 2004
$500k
PET CAMERA FOR BRAIN IMAGING: SCHIZOPHRENIA, BIPOLAR DISORDERS10RR019933 · NCRR · MASSACHUSETTS GENERAL HOSPITAL · PI SORENSEN, ALMA GREGORY · 2006 to 2006
$500k
Carbon-11 Radiopharmaceutical Production SystemS10RR026666 · NCRR · MASSACHUSETTS GENERAL HOSPITAL · PI BROWNELL, ANNA-LIISA · 2010 to 2010
$462k
Developing new PET imaging probes for orexin 1 receptorsR03DA048123 · NIDA · MASSACHUSETTS GENERAL HOSPITAL · PI WANG, CHANGNING · 2019 to 2019
$242k
NCRR NIH HHS S10 RR017208NCRR NIH HHS S10 RR019933NCRR NIH HHS S10 RR022976NCRR NIH HHS S10 RR023401NCRR NIH HHS S10 RR026666NIBIB NIH HHS P41 EB015896NIDA NIH HHS R03 DA048123NIH HHS S10 OD023517NIH HHS S10 OD025234
6 · The paper itself

Abstract

The orexin receptors (OXRs) have been involved in multiple physiological and neuropsychiatric functions. Identification of PET imaging probes specifically targeting OXRs enables us to better understand the OX system. Seltorexant (JNJ-42847922) is a potent OX

Indexed as

NeuroimagingPositron-Emission TomographyAnimalsBrainMiceOrexin ReceptorsCd200r1 protein, mouseOrexin ReceptorsImagingOrexin receptorsPETRadiotracer

Identifiers

PMID35397430
PMCPMC9050936
OpenAlexW4223486794

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.