Evidence map›Paper›PMID 35397356›Full record

ArticleThe American journal of emergency medicine2022

Emergency department versus community screening on hepatitis C follow-up care.

Austin T Jones, Lisa Moreno-Walton, Torrence Tran, Christopher Briones, Kanayo Okeke-Eweni, Rachael Stevens, Kacie Isaacson, Hua He, Patricia J Kissinger

Abstract read
In one paragraph

Article in The American journal of emergency medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Clinical- and Cost-Effectiveness of Liver Disease Staging in Hepatitis C Virus Infection: A Microsimulation Study.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2025
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Austin T JonesDepartment of Emergency Medicine, Denver Health Medical Center, Denver, CO, USA. Electronic address: austin.jones@denverem.org.
Lisa Moreno-WaltonSection of Emergency Medicine, Louisiana State University Health Sciences Center, New Orleans, LA, USA.
Torrence TranDepartment of Emergency Medicine, University of California Los Angeles Medical Center, Los Angeles, CA, USA.
Christopher BrionesDepartment of Emergency Medicine, University of California Los Angeles Medical Center, Los Angeles, CA, USA.
Kanayo Okeke-EweniSection of Emergency Medicine, Louisiana State University Health Sciences Center, New Orleans, LA, USA.
Rachael StevensTulane University School of Medicine, New Orleans, LA, USA.
Kacie IsaacsonDepartment of Emergency Medicine, Emory University, Atlanta, GA, USA.
Hua HeDepartment of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, USA.
Patricia J KissingerDepartment of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, USA.

Funding

UAB Center for Clinical and Translational Sciences (CCTS)TL1TR001418 · NCATS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI SAAG, KENNETH G · 2015 to 2018
$2.1M
NCATS NIH HHS TL1 TR001418
6 · The paper itself

Abstract

objectivesEmergency department (ED) hepatitis C virus (HCV) screening programs are proliferating, and it is unknown whether EDs are more effective than traditional community screening at promoting HCV follow-up care. The objective of this study was to investigate whether patients screened HCV seropositive (HCV+) in the ED are linked to care and retained in treatment more successfully than patients screened HCV+ in the community.

methodsA retrospective cohort study was performed including patients screened HCV+ at twelve screening facilities in New Orleans, LA from March 1, 2015 to July 31, 2017. Treatment outcomes, including retention and time to follow-up care, were assessed using the HCV continuum of care model.

resultsED patients (n = 3008) were significantly more likely to achieve RNA confirmation (aRR = 1.91, 95% CI = 1.54-2.37), initiate HCV therapy (aRR = 2.23 [1.76-2.83]), complete HCV therapy (aRR = 1.77 [1.40-2.24]), and achieve HCV functional cure (aRR = 2.80 [1.09-7.23]) compared to community-screened patients (n = 322). ED screening was associated with decreased likelihood of fibrosis staging (aRR = 0.65 [0.51-0.82]) and no difference in linkage to specialty care (aRR = 1.03 [0.69-1.53]). In time to follow up, RNA confirmation occurred at faster rates in the ED (aHR = 2.26 [1.86-2.72]), although these patients completed fibrosis staging at slower rates (aHR = 0.49 [0.38-0.63]) than community patients.

conclusionsCompared to community screening, HCV screening in the ED was associated with higher rates of disease confirmation, treatment initiation/completion, and cure. Our findings provide new evidence that EDs may be the most effective setting to screen patients for HCV to promote follow-up care.

Indexed as

HepacivirusHepatitis CAftercareEmergency Service, HospitalFibrosisHumansMass ScreeningRetrospective StudiesRNARNACommunity clinicEmergency departmentHepatitis CLinkage to careScreening

Identifiers

PMID35397356
PMCPMC9121811

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.