ArticleActa paediatrica (Oslo, Norway : 1992)2022
Perinatal risk factors for mortality in very preterm infants-A nationwide, population-based discriminant analysis.
Article in Acta paediatrica (Oslo, Norway : 1992), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 6 citations in OpenAlex.
- Feasibility and placement accuracy of a sensor-guided intraosseous device with an automated stop in a small-bone rat cadaver model: a single-arm pilot study.Resuscitation plus · 2026Article
- Mortality and morbidity in very preterm infants in Switzerland spanning 16 years (2006-2021).BMJ paediatrics open · 2026Article
- Two-year neurodevelopmental outcome in preterm neonates with cerebral oxygenation monitoring after birth: a multinational, multicenter retrospective follow-up study of the COSGOD III trial.Frontiers in pediatrics · 2026Article
- Neonatal Factors Associated with Mortality Among Preterm Infants Admitted to Neonatal Intensive Care in a Peruvian National Hospital.Healthcare (Basel, Switzerland) · 2025Article
- Reduced IL-17A levels in neonates born to mothers with diabetes mellitus or infection during pregnancy.Frontiers in pediatrics · 2025Article
- Identification of Neonatal Factors Predicting Pre-Discharge Mortality in Extremely Preterm or Extremely Low Birth Weight Infants: A Historical Cohort Study.Children (Basel, Switzerland) · 2024Article
- Perinatal risk factors for mortality in very preterm infants-A nationwide, population-based discriminant analysis.Acta paediatrica (Oslo, Norway : 1992) · 2022Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
aimTo assess the strength of associations between interrelated perinatal risk factors and mortality in very preterm infants.
methodsInformation on all live-born infants delivered in Sweden at 22-31 weeks of gestational age (GA) from 2011 to 2019 was gathered from the Swedish Neonatal Quality Register, excluding infants with major malformations or not resuscitated because of anticipated poor prognosis. Twenty-seven perinatal risk factors available at birth were exposures and in-hospital mortality outcome. Orthogonal partial least squares discriminant analysis was applied to assess proximity between individual risk factors and mortality, and receiver operating characteristic (ROC) curves were used to estimate discriminant ability.
resultsIn total, 638 of 8,396 (7.6%) infants died. Thirteen risk factors discriminated reduced mortality; the most important were higher Apgar scores at 5 and 10 min, GA and birthweight. Restricting the analysis to preterm infants <28 weeks' GA (n = 2939, 16.9% mortality) added antenatal corticosteroid therapy as significantly associated with lower mortality. The area under the ROC curve (the C-statistic) using all risk factors was 0.86, as determined after both internal and external validation.
conclusionApgar scores, gestational age and birthweight show stronger associations with mortality in very preterm infants than several other perinatal risk factors available at birth.
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