Evidence map›Paper›PMID 35397062›Full record

ArticleBrain imaging and behavior2022

Altered topological properties of the intrinsic functional brain network in patients with right-sided unilateral hearing loss caused by acoustic neuroma.

Zhiyuan Fan, Zhen Fan, Tianming Qiu, Liuxun Hu, Yuan Shi, Yunman Xia, Xiaoyi Sun, Yingjun Liu, Sichen Li, Mingrui Xia and 1 more

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Article in Brain imaging and behavior, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Zhiyuan Fan *Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, 20040, China.
Zhen Fan *Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, 20040, China.
Tianming QiuDepartment of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, 20040, China.
Liuxun HuDepartment of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, 20040, China.
Yuan ShiDepartment of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, 20040, China.
Yunman XiaState Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, 100875, China.
Xiaoyi SunState Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, 100875, China.
Yingjun LiuDepartment of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, 20040, China.
Sichen LiDepartment of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, 20040, China.
Mingrui XiaState Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, 100875, China. mxia@bnu.edu.cn.
Wei ZhuDepartment of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, 20040, China. drzhuwei@fudan.edu.cn.ORCID http://orcid.org/0000-0001-7190-7476
Fudan University · CNBeijing Normal University · CNShanghai Medical College of Fudan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neuroimaging studies have identified alterations in functional connectivity between specific brain regions in patients with unilateral hearing loss (UHL) and different influence of the side of UHL on neural plasticity. However, little is known about changes of whole-brain functional networks in patients with UHL and whether differences exist in topological organization between right-sided UHL (RUHL) and left-sided UHL (LUHL). To address this issue, we employed resting-state fMRI (rs-fMRI) and graph-theoretical approaches to investigate the topological alterations of brain functional connectomes in patients with RUHL and LUHL. Data from 44 patients with UHL (including 22 RUHL patients and 22 LUHL patients) and 37 healthy control subjects (HCs) were collected. Functional brain networks were constructed for each participant, following by graph-theoretical network analyses at connectional and global (e.g., small-worldness) levels. The correlations between brain network topologies and clinical variables were further studied. Using network-based analysis, we found a subnetwork in the visual cortex which had significantly lower connectivity strength in patients with RUHL as compared to HCs. At global level, all participants showed small-world architecture in functional brain networks, however, significantly lower normalized clustering coefficient and small-worldness were observed in patients with RUHL than in HCs. Moreover, these abnormal network metrics were demonstrated to be correlated with the clinical variables and cognitive performance of patients with RUHL. Notably, no significant alterations in the functional brain networks were found in patients with LUHL. Our findings demonstrate that RUHL (rather than LUHL) is accompanied with aberrant topological organization of the functional brain connectome, indicating different pathophysiological mechanisms between RUHL and LUHL from a viewpoint of network topology.

Indexed as

BrainHearing Loss, UnilateralNeuroma, AcousticBrain MappingConnectomeHumansMagnetic Resonance ImagingConnectomeGraph theoryNetwork-based statisticsSmall-worldUnilateral hearing loss

Identifiers

PMID35397062
OpenAlexW4223509829

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.