Evidence map›Paper›PMID 35397018›Full record

ReviewMetabolomics : Official journal of the Metabolomic Society2022

Reference materials for MS-based untargeted metabolomics and lipidomics: a review by the metabolomics quality assurance and quality control consortium (mQACC).

Katrice A Lippa, Juan J Aristizabal-Henao, Richard D Beger, John A Bowden, Corey Broeckling, Chris Beecher, W Clay Davis, Warwick B Dunn, Roberto Flores, Royston Goodacre and 16 more

Open access · hybridAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Metabolomics : Official journal of the Metabolomic Society, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers.

0numbers the graph read from it
0cells of the map it votes in
66citing papers in PubMed
10.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

66 citing papers in PubMed, 121 citations in OpenAlex.

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6 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors at 19 institutions in 5 countries.

Katrice A LippaChemical Sciences Division, National Institute of Standards and Technology (NIST), Gaithersburg, MD, 20899, USA.
Juan J Aristizabal-HenaoDepartment of Physiological Sciences, Center for Environmental and Human Toxicology, College of Veterinary Medicine, University of Florida, Gainesville, FL, 32610, USA.
Richard D BegerDivision of Systems Biology, National Center for Toxicological Research, U.S. Food and Drug Administration (FDA), Jefferson, AR, 72079, USA.
John A BowdenDepartment of Physiological Sciences, Center for Environmental and Human Toxicology, College of Veterinary Medicine, University of Florida, Gainesville, FL, 32610, USA.
Corey BroecklingAnalytical Resources Core: Bioanalysis and Omics Center, Colorado State University, Fort Collins, CO, 80523, USA.
Chris BeecherIROA Technologies, Chapel Hill, NC, 27517, USA.
W Clay DavisChemical Sciences Division, National Institute of Standards and Technology (NIST), Charleston, SC, 29412, USA.
Warwick B DunnSchool of Biosciences, Institute of Metabolism and Systems Research and Phenome Centre Birmingham, University of Birmingham, Birmingham, B15, 2TT, UK.
Roberto FloresDivision of Program Coordination, Planning and Strategic Initiatives, Office of Nutrition Research, Office of the Director, National Institutes of Health (NIH), Bethesda, MD, 20892, USA.
Royston GoodacreDepartment of Biochemistry and Systems Biology, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, BioSciences Building, Crown St., Liverpool, L69 7ZB, UK.
Gonçalo J GouveiaDepartment of Biochemistry and Molecular Biology, University of Georgia, Athens, GA, 30602, USA.
Amy C HarmsBiomedical Metabolomics Facility Leiden, Leiden University, Einsteinweg 55, 2333 CC, Leiden, The Netherlands.
Thomas HartungBloomberg School of Public Health, Environmental Health and Engineering, Johns Hopkins University, Baltimore, MD, 21205, USA.
Christina M JonesChemical Sciences Division, National Institute of Standards and Technology (NIST), Gaithersburg, MD, 20899, USA.
Matthew R LewisNational Phenome Centre, Imperial College London, London, SW7 2AZ, UK.
Ioanna NtaiThermo Fisher Scientific, San Jose, CA, 95134, USA.
Andrew J PercyCambridge Isotope Laboratories, Inc., Tewksbury, MA, 01876, USA.
Dan RafteryNorthwest Metabolomics Research Center, University of Washington, Seattle, WA, 98109, USA.
Tracey B SchockChemical Sciences Division, National Institute of Standards and Technology (NIST), Charleston, SC, 29412, USA.
Jinchun SunDivision of Systems Biology, National Center for Toxicological Research, U.S. Food and Drug Administration (FDA), Jefferson, AR, 72079, USA.
Georgios TheodoridisDepartment of Chemistry, Aristotle University, 54124, Thessaloniki, Greece.
Fariba TayyariDepartment of Internal Medicine, University of Iowa, Iowa City, IA, 52242, USA.
Federico TortaCentre for Life Sciences, National University of Singapore, 28 Medical Drive, Singapore, 117456, Singapore.
Candice Z UlmerCenters for Disease Control and Prevention (CDC), Atlanta, GA, 30341, USA.
Ian WilsonComputational & Systems Medicine, Imperial College, Exhibition Rd, London, SW7 2AZ, UK.
Baljit K UbhiMOBILion Systems Inc., 4 Hillman Drive Suite 130, Chadds Ford, PA, 19317, USA. drbkubhi@gmail.com.ORCID 0000-0003-3010-7135
National Institute of Standards and Technology · USImperial College London · GBNational Center for Toxicological Research · USUniversity of Florida · USAristotle University of Thessaloniki · GRCenters for Disease Control and Prevention · USColorado State University · USHill Engineering (United States) · USInternational Isotopes (United States) · USJohns Hopkins University · USLeiden University · NLNational Institutes of Health · USNational University of Singapore · SGThermo Fisher Scientific (United States) · USUniversity of Birmingham · GBUniversity of Georgia · USUniversity of Iowa · USUniversity of Liverpool · GBUniversity of Washington · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThe metabolomics quality assurance and quality control consortium (mQACC) is enabling the identification, development, prioritization, and promotion of suitable reference materials (RMs) to be used in quality assurance (QA) and quality control (QC) for untargeted metabolomics research.

objectivesThis review aims to highlight current RMs, and methodologies used within untargeted metabolomics and lipidomics communities to ensure standardization of results obtained from data analysis, interpretation and cross-study, and cross-laboratory comparisons. The essence of the aims is also applicable to other 'omics areas that generate high dimensional data.

resultsThe potential for game-changing biochemical discoveries through mass spectrometry-based (MS) untargeted metabolomics and lipidomics are predicated on the evolution of more confident qualitative (and eventually quantitative) results from research laboratories. RMs are thus critical QC tools to be able to assure standardization, comparability, repeatability and reproducibility for untargeted data analysis, interpretation, to compare data within and across studies and across multiple laboratories. Standard operating procedures (SOPs) that promote, describe and exemplify the use of RMs will also improve QC for the metabolomics and lipidomics communities.

conclusionsThe application of RMs described in this review may significantly improve data quality to support metabolomics and lipidomics research. The continued development and deployment of new RMs, together with interlaboratory studies and educational outreach and training, will further promote sound QA practices in the community.

Indexed as

LipidomicsMetabolomicsMass SpectrometryQuality ControlReproducibility of ResultsCertified reference materialsInternal standardsLipidomicsMass spectrometryMetabolomicsMetabolomics quality assurance and quality control consortium (mQACC)Reference materialsUntargeted analysis

Identifiers

PMID35397018
PMCPMC8994740
OpenAlexW4223546795

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.