Evidence map›Paper›PMID 35396815›Full record

SynthesisPediatric obesity2022

Examining the sustainability of effects of early childhood obesity prevention interventions: Follow-up of the EPOCH individual participant data prospective meta-analysis.

Anna Lene Seidler, Kylie E Hunter, Louise Baur, David Espinoza, Rachael W Taylor, Li Ming Wen, Kylie D Hesketh, Karen Campbell, Lynne Daniels, Seema Mihrshahi and 3 more

Abstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Pediatric obesity, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Trial
  5. Article
  6. Article
  7. Review
  8. Article
  9. Child and adolescent obesity.Nature reviews. Disease primers · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Anna Lene SeidlerNHMRC Clinical Trials Centre, University of Sydney, Camperdown, New South Wales, Australia.ORCID 0000-0002-0027-1623
Kylie E HunterNHMRC Clinical Trials Centre, University of Sydney, Camperdown, New South Wales, Australia.ORCID 0000-0002-2796-9220
Louise BaurSpecialty of Child and Adolescent Health, University of Sydney, Camperdown, New South Wales, Australia.
David EspinozaNHMRC Clinical Trials Centre, University of Sydney, Camperdown, New South Wales, Australia.
Rachael W TaylorDepartment of Medicine, University of Otago, Dunedin, New Zealand.ORCID 0000-0001-9516-2253
Li Ming WenHealth Promotion Unit, Sydney Local Health District, School of Public Health, University of Sydney, Camperdown, New South Wales, Australia.ORCID 0000-0003-1381-4022
Kylie D HeskethInstitute for Physical Activity and Nutrition, Deakin University, Geelong, Victoria, Australia.
Karen CampbellInstitute for Physical Activity and Nutrition, Deakin University, Geelong, Victoria, Australia.
Lynne DanielsCentre Child Health Research, School Exercise Nutrition Sciences, Queensland University Technology, Brisbane, Queensland, Australia.
Seema MihrshahiDepartment of Health Systems and Populations, Faculty of Medicine, Health and Human Sciences, Macquarie University, New South Wales, Australia.
Chris RisselSydney School of Public Health, University of Sydney, Camperdown, New South Wales, Australia.
Barry TaylorDepartment of Women's and Children's Health, University of Otago, Dunedin, New Zealand.
Lisa M AskieNHMRC Clinical Trials Centre, University of Sydney, Camperdown, New South Wales, Australia.ORCID 0000-0002-8934-5544

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAlthough early childhood obesity prevention has become an important issue internationally, little evidence exists regarding longer term effects (i.e., sustainability) of early interventions.

objectiveTo determine whether intervention benefits at 2 years of age were sustained at 3.5 and 5 years.

methodsFollow-up of the Early Prevention of Obesity in Children (EPOCH) individual participant data prospective meta-analysis of four randomized controlled trials including 2196 mother-child dyads at baseline. Interventions were home- or community-based, commenced within 6 months of birth, ended by 2 years of age, and comprised multiple sessions. Controls received standard care. BMI z-score (primary outcome), other anthropometric measures and weight-related behaviours were initially measured at 1.5-2 years and followed up at 3.5 and 5 years.

resultsPositive intervention effects on BMI z-scores at 1.5-2 years of age were not apparent by 3.5 years (-0.04 adjusted mean difference; 95% CI:-0.14, 0.06; p = 0.424), and 5 years (0.03; 95% CI: -0.08, 0.14; p = 0.60). While prolonged intervention benefits were detected for a few, but not the majority of, weight-related behaviours at 3.5 years, these effects diminished over time.

conclusionThis meta-analysis found that initial positive effects of childhood obesity interventions faded out after interventions ended, pointing toward the importance of a suite of interventions implemented at multiple stages across childhood.

Indexed as

Pediatric ObesityChildChild, PreschoolFollow-Up StudiesHumansProspective Studieschildhood obesityearly interventionindividual participant datapreventionprospective meta-analysissustainability of intervention effects

Identifiers

PMID35396815
PMCPMC9541553

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.