ArticleNPJ biofilms and microbiomes2022
Variation of Antigen 43 self-association modulates bacterial compacting within aggregates and biofilms.
Article in NPJ biofilms and microbiomes, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Genomic survey uncovers the emergence of a multidrug-resistant dominant lineage in Proteus mirabilis populations.npj antimicrobials and resistance · 2026Article
- A quorum-sensing molecule fromProceedings of the National Academy of Sciences of the United States of America · 2026Article
- Membrane perturbation by the last-resort antibiotic polymyxin B drives biphasic regulation of horizontal gene transfer.The ISME journal · 2026Article
- Bioactive Compounds as a Potential Inhibitor of Biofilm Production: AnCurrent drug discovery technologies · 2026Article
- UropathogenicInternational journal of molecular sciences · 2025Article
- Antigen 43 associated withMicrobiology spectrum · 2025Article
- Collective condensation and auto-aggregation of Escherichia coli in uniform acidic environments.Communications biology · 2024Article
- FdeC expression regulates motility and adhesion of the avian pathogenic Escherichia coli strain IMT5155.Veterinary research · 2024Article
- The biofilm community resurfaces: new findings and post-pandemic progress.Journal of bacteriology · 2023Review
- Genome-Wide Analysis of Antigen 43 (Ag43) Variants: New Insights in Their Diversity, Distribution and Prevalence in Bacteria.International journal of molecular sciences · 2023Article
- Crystal structure of a subtilisin-like autotransporter passenger domain reveals insights into its cytotoxic function.Nature communications · 2023Article
- Phylogenetic Classification and Functional Review of Autotransporters.Frontiers in immunology · 2022Review
Corrections and comments
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Authors and funding
14 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The formation of aggregates and biofilms enhances bacterial colonisation and infection progression by affording protection from antibiotics and host immune factors. Despite these advantages there is a trade-off, whereby bacterial dissemination is reduced. As such, biofilm development needs to be controlled to suit adaptation to different environments. Here we investigate members from one of largest groups of bacterial adhesins, the autotransporters, for their critical role in the assembly of bacterial aggregates and biofilms. We describe the structural and functional characterisation of autotransporter Ag43 variants from different Escherichia coli pathotypes. We show that specific interactions between amino acids on the contacting interfaces of adjacent Ag43 proteins drives a common mode of trans-association that leads to cell clumping. Furthermore, subtle variation of these interactions alters aggregation kinetics and the degree of compacting within cell clusters. Together, our structure-function investigation reveals an underlying molecular basis for variations in the density of bacterial communities.
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Registered trials
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