SynthesisCommunications biology2022
Meta-analysis of genome-wide association studies identifies ancestry-specific associations underlying circulating total tau levels.
Abstract readMeta-Analysis
In one paragraph
Synthesis in Communications biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
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26citing papers in PubMed, 1 pooled it
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What it found
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Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Genome-wide association study meta-analysis of neurofilament light (NfL) levels in blood reveals novel loci related to neurodegeneration.Communications biology · 2024Pooled it
- Evaluating causal links between retinal thickness, Alzheimer's disease, and circulating total-tau: evidence from Mendelian randomization and colocalization analysis.European archives of psychiatry and clinical neuroscience · 2026Article
- The Association Between Alzheimer's Disease-Related Biomarkers And Parkinson's Disease Based On Single-Cell Sequencing Analysis Combined With Mendelian Randomization.Journal of molecular neuroscience : MN · 2026Article
- Mapping Fusarium wilt and sterility mosaic disease resistance-associated genomic regions and haplotype variants in pigeonpea.BMC plant biology · 2026Article
- HIF3A-mediated aberrant activation of TXNIP promotes Alzheimer's disease progression.Scientific reports · 2026Article
- Association between Alzheimer's disease-related genes and neurodegenerative blood-based biomarkers in Indian adults.Frontiers in aging neuroscience · 2026Article
- Quo Vadis translational neuroscience?Translational neuroscience · 2026Review
- Novel early-onset Alzheimer-associated genes influence risk through dysregulation of glutamate, immune activation, and intracellular signaling pathways.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- A structural haplotype in the 17q21.31 MAPT region is associated with increased risk for chronic traumatic encephalopathy endophenotypes.Cell reports. Medicine · 2025Article
- Metabolomic signatures of cognitive function in a type 2 Diabetes-Enriched cohort.Scientific reports · 2025Article
- Interrogating DNA methylation associated with Lewy body pathology in a cross brain-region and multi-cohort study.medRxiv : the preprint server for health sciences · 2025Article
- Excessive Alcohol Use as a Risk Factor for Alzheimer's Disease: Epidemiological and Preclinical Evidence.Advances in experimental medicine and biology · 2025Review
- Epigenetic Modifiers: Exploring the Roles of Histone Methyltransferases and Demethylases in Cancer and Neurodegeneration.Biology · 2024Review
- Is the Relationship Between Cardiovascular Disease and Alzheimer's Disease Genetic? A Scoping Review.Genes · 2024Article
- Trends in Global Burden of Alzheimer's Disease and Other Dementias Attributable to High Fasting Plasma Glucose, 1990-2021.Medicina (Kaunas, Lithuania) · 2024Article
- Integration of estimated regional gene expression with neuroimaging and clinical phenotypes at biobank scale.PLoS biology · 2024Article
- There Is No Direct Causal Relationship Between Coronary Artery Disease and Alzheimer Disease: A Bidirectional Mendelian Randomization Study.Journal of the American Heart Association · 2024Article
- Role of Tau Protein in Neurodegenerative Diseases and Development of Its Targeted Drugs: A Literature Review.Molecules (Basel, Switzerland) · 2024Review
- Cerebral Amyloidosis in Individuals with Subjective Cognitive Decline: From Genetic Predisposition to Actual Cerebrospinal Fluid Measurements.Biomedicines · 2024Article
- Inflammation, Autoimmunity and Neurodegenerative Diseases, Therapeutics and Beyond.Current neuropharmacology · 2024Article
Corrections and comments
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Authors and funding
36 authors.
Chloé Sarnowski *Department of Epidemiology, Human Genetics, and Environmental Sciences, University of Texas Health Science Center at Houston, Houston, TX, USA. Chloe.Sarnowski@uth.tmc.edu.ORCID http://orcid.org/0000-0002-6090-7099
Mohsen Ghanbari *Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands.ORCID http://orcid.org/0000-0002-9476-7143
Joshua C Bis *Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.ORCID http://orcid.org/0000-0002-3409-1110
Mark Logue *National Center for PTSD, Behavioral Sciences Division, VA Boston Healthcare System, Boston, MA, USA.
Myriam Fornage *University of Texas Health Sciences Center at Houston, Houston, TX, USA.ORCID http://orcid.org/0000-0003-0677-8158
Aniket Mishra *University of Bordeaux, Inserm, Bordeaux Population Health Research Center, team VINTAGE, UMR 1219, F-33000, Bordeaux, France.ORCID http://orcid.org/0000-0002-8141-1543
Shahzad AhmadDepartment of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands.ORCID http://orcid.org/0000-0002-8658-3790
Alexa S BeiserDepartment of Biostatistics, Boston University School of Public Health, Boston, MA, USA.
Eric BoerwinkleUniversity of Texas Health Sciences Center at Houston, Houston, TX, USA.
Vincent BouteloupCentre Inserm U1219 Bordeaux Population Health, CIC1401-EC, Institut de Santé Publique, d'Epidémiologie et de Développement, Université de Bordeaux, CHU de Bordeaux, Pôle Santé Publique, Bordeaux, France.
Vincent ChourakiUniv. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1167 - RID-AGE- LabEx DISTALZ - Risk factors and molecular determinants of aging diseases, F-59000, Lille, France.
L Adrienne CupplesDepartment of Biostatistics, Boston University School of Public Health, Boston, MA, USA.ORCID http://orcid.org/0000-0003-0273-7965
Vincent DamotteUniv. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1167 - RID-AGE- LabEx DISTALZ - Risk factors and molecular determinants of aging diseases, F-59000, Lille, France.
Charles S DeCarliDepartment of Neurology and Center for Neuroscience, University of California at Davis, Davis, CA, USA.
Anita L DeStefanoDepartment of Biostatistics, Boston University School of Public Health, Boston, MA, USA.
Luc DjousséDepartment of Medicine, Division of Aging, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Alison E FohnerInstitute of Public Health Genetics and Department of Epidemiology and Cardiovascular Health Research Unit, University of Washington, Seattle, WA, USA.
Carol E FranzDepartment of Psychiatry and Center for Behavior Genetics of Aging, University of California, San Diego, La Jolla, CA, USA.ORCID http://orcid.org/0000-0002-8987-1755
Tiffany F KautzGlenn Biggs Institute for Alzheimer's & Neurodegenerative Diseases, University of Texas Health Sciences Center, San Antonio, TX, USA.
Jean-Charles LambertUniv. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1167 - RID-AGE- LabEx DISTALZ - Risk factors and molecular determinants of aging diseases, F-59000, Lille, France.ORCID http://orcid.org/0000-0003-0829-7817
Michael J LyonsDepartment of Psychology and Brain Sciences, Boston University, Boston, MA, USA.
Thomas H MosleyUniversity of Mississippi Medical Center, Jackson, MS, USA.
Kenneth J MukamalBeth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0001-8450-6970
Matthew P PaseTurner Institute for Brain and Mental Health, Monash University, Melbourne, VIC, Australia.ORCID http://orcid.org/0000-0002-4143-8485
Eliana C Portilla FernandezDepartment of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands.
Robert A RissmanDepartment of Neurosciences, University of California, San Diego, La Jolla, CA, USA.
Claudia L SatizabalBoston University and the NHLBI's Framingham Heart Study, Boston, MA, USA.
Ramachandran S VasanBoston University and the NHLBI's Framingham Heart Study, Boston, MA, USA.ORCID http://orcid.org/0000-0001-7357-5970
Amber YaqubDepartment of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands.ORCID http://orcid.org/0000-0002-3579-8054
Stephanie DebetteUniversity of Bordeaux, Inserm, Bordeaux Population Health Research Center, team VINTAGE, UMR 1219, F-33000, Bordeaux, France.ORCID http://orcid.org/0000-0001-8675-7968
Carole DufouilBordeaux University Hospital, Department of Neurology, Institute for Neurodegenerative Diseases, Bordeaux, France.ORCID http://orcid.org/0000-0003-2442-4476
Lenore J LaunerNational Institute on Aging, Baltimore, MD, USA.ORCID http://orcid.org/0000-0002-3238-7612
William S KremenDepartment of Psychiatry and Center for Behavior Genetics of Aging, University of California, San Diego, La Jolla, CA, USA.ORCID http://orcid.org/0000-0002-8629-5609
William T LongstrethDepartments of Neurology and Epidemiology, University of Washington, Seattle, WA, USA.
M Arfan IkramDepartment of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands.ORCID http://orcid.org/0000-0003-0372-8585
Sudha SeshadriBoston University and the NHLBI's Framingham Heart Study, Boston, MA, USA.
Funding
The VETSA Longitudinal Twin Study of Cognition and Aging (VETSA 4)R01AG050595 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ELMAN, JEREMY A, FRANZ, CAROL ELAINE · 2015 to 2024
$28.0MUSCADRC Diversity Supplement PachicanoP30AG066530 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Hussein N Yassine · 2020 to 2026
$27.8MSouth Texas Alzheimer's Disease Research CenterP30AG066546 · NIA · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Mohamad Habes · 2021 to 2026
$24.0MPRECURSORS OF STROKE INCIDENCE AND PROGNOSISR01NS017950 · NINDS · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Hugo Javier Aparicio, Jose Rafael Romero · 1985 to 2026
$22.9MThe VETSA Longitudinal MRI Twin Study of AgingR01AG022381 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI KREMEN, WILLIAM S. · 2003 to 2019
$22.3MTemporal Trends, Novel Imaging and Molecular Characterization of Preclinical and Clinical Alzheimer's Disease in the Framingham CohortsR01AG054076 · NIA · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI DECARLI, CHARLES, SESHADRI, SUDHA · 2016 to 2020
$12.3MARIC Neurocognitive Study (ARIC-NCS) Renewal 2 of 5U01HL096917 · NHLBI · UNIVERSITY OF MISSISSIPPI MED CTR · PI MOSLEY, THOMAS H · 2010 to 2018
$11.9MTherapeutic target discovery in ADSP data via comprehensive whole-genome analysis incorporating ethnic diversity and systems approachesU01AG058589 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI BOERWINKLE, ERIC A., DE JAGER, PHILIP L · 2018 to 2022
$11.1MCHARGE Consortium: Omics Discovery for CVD and Aging PhenotypesR01HL105756 · NHLBI · UNIVERSITY OF WASHINGTON · PI Bruce M Psaty, NICHOLAS L SMITH · 2011 to 2026
$9.5MCognitively Healthy Nonagenarians in the Cross Cohort Collaboration (CCC)RF1AG059421 · NIA · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI SESHADRI, SUDHA · 2018 to 2018
$6.1MCognitively Healthy Nonagenarians in the Cross Cohort Collaboration (CCC)R01AG059421 · NIA · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Stephanie Anne-Carine Debette, Carole Dufouil · 2026 to 2026
$4.7MGenetic Predictors, Transcriptomic Biomarkers, & Neurobiological Signatures of Resilience to Alzheimer's DiseaseR01AG064955 · NIA · UPSTATE MEDICAL UNIVERSITY · PI FENNEMA-NOTESTINE, CHRISTINE, GLATT, STEPHEN J · 2019 to 2023
$3.8MNHLBI NIH HHS R01 HL093029NHLBI NIH HHS R01 HL105756NHLBI NIH HHS U01 HL096917NIA NIH HHS K01 AG071689NIA NIH HHS K99 AG066849NIA NIH HHS P30 AG066530NIA NIH HHS P30 AG066546NIA NIH HHS R01 AG022381NIA NIH HHS R01 AG049607NIA NIH HHS R01 AG050595NIA NIH HHS R01 AG054076NIA NIH HHS R01 AG059421NIA NIH HHS R01 AG064955NIA NIH HHS RF1 AG059421NIA NIH HHS U01 AG049505NIA NIH HHS U01 AG052409NIA NIH HHS U01 AG058589NINDS NIH HHS R01 NS017950NINDS NIH HHS UH2 NS100605NINDS NIH HHS UH3 NS100605
Abstract
Circulating total-tau levels can be used as an endophenotype to identify genetic risk factors for tauopathies and related neurological disorders. Here, we confirmed and better characterized the association of the 17q21 MAPT locus with circulating total-tau in 14,721 European participants and identified three novel loci in 953 African American participants (4q31, 5p13, and 6q25) at P < 5 × 10
Indexed as
Alzheimer DiseaseTauopathiesBlack or African AmericanExomeGenome-Wide Association StudyHumans
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