ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2022
Spatial Learning Drives Rapid Goal Representation in Hippocampal Ripples without Place Field Accumulation or Goal-Oriented Theta Sequences.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 36 citations in OpenAlex.
- Hippocampal theta sweeps indicate goal direction during navigation.Nature neuroscience · 2026Article
- Transcriptomic Profiling in Aged Mice Reveals an Association Between Sevoflurane Anesthesia and Neurocognitive Dysfunction.Cellular and molecular neurobiology · 2026Article
- Between planning and map building: Prioritizing replay when future goals are uncertain.Neuron · 2025Review
- Prioritizing replay when future goals are unknown.bioRxiv : the preprint server for biology · 2025Article
- Hippocampal Place Cell Sequences Are Impaired in a Rat Model of Fragile X Syndrome.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Hippocampal place cell sequences are impaired in a rat model of Fragile X Syndrome.bioRxiv : the preprint server for biology · 2025Article
- Formation and retrieval of cell assemblies in a biologically realistic spiking neural network model of area CA3 in the mouse hippocampus.Journal of computational neuroscience · 2024Article
- Identification of a Hippocampus-to-Zona Incerta Projection involved in Motor Learning.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Remapping revisited: how the hippocampus represents different spaces.Nature reviews. Neuroscience · 2024Review
- Estimating neuronal firing density: A quantitative analysis of firing rate map algorithms.PLoS computational biology · 2023Article
- Bidirectional synaptic changes in deep and superficial hippocampal neurons following in vivo activity.Neuron · 2023Article
- A theory of hippocampal theta correlations accounting for extrinsic and intrinsic sequences.eLife · 2023Article
- Neural ensembles in navigation: From single cells to population codes.Current opinion in neurobiology · 2023Review
- Hippocampal representations of foraging trajectories depend upon spatial context.Nature neuroscience · 2022Article
- Uncovering the Hippocampal Mechanisms Underpinning Spatial Learning and Flexible Navigation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Article
- Neuronal signature of spatial decision-making during navigation by freely moving rats by using calcium imaging.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Frequency matters: how changes in hippocampal theta frequency can influence temporal coding, anxiety-reduction, and memory.Frontiers in systems neuroscience · 2022Article
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Abstract
The hippocampus is critical for rapid acquisition of many forms of memory, although the circuit-level mechanisms through which the hippocampus rapidly consolidates novel information are unknown. Here, the activity of large ensembles of hippocampal neurons in adult male Long-Evans rats was monitored across a period of rapid spatial learning to assess how the network changes during the initial phases of memory formation and retrieval. In contrast to several reports, the hippocampal network did not display enhanced representation of the goal location via accumulation of place fields or elevated firing rates at the goal. Rather, population activity rates increased globally as a function of experience. These alterations in activity were mirrored in the power of the theta oscillation and in the quality of theta sequences, without preferential encoding of paths to the learned goal location. In contrast, during brief "offline" pauses in movement, representation of a novel goal location emerged rapidly in ripples, preceding other changes in network activity. These data demonstrate that the hippocampal network can facilitate active navigation without enhanced goal representation during periods of active movement, and further indicate that goal representation in hippocampal ripples before movement onset supports subsequent navigation, possibly through activation of downstream cortical networks.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.