ArticleBMJ global health2022
Estimating the contribution of transmission in primary healthcare clinics to community-wide TB disease incidence, and the impact of infection prevention and control interventions, in KwaZulu-Natal, South Africa.
Article in BMJ global health, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.
- Agent-based modelling of Mycobacterium tuberculosis transmission: a systematic review.BMC infectious diseases · 2024Pooled it
- Towards ending tuberculosis in South Africa: an uncertainty analysis of the programmes and factors most critical to future declines.Global health action · 2026Article
- Reducing spatial clustering to prevent tuberculosis transmission in a busy Zambian hospital: a modelling study based on person movements, environmental and clinical data.medRxiv : the preprint server for health sciences · 2025Article
- Knowledge, practices, and concerns of tuberculosis healthcare workers at primary settings in western China: a multi-center cross-sectional study.Infectious diseases of poverty · 2025Article
- Estimating Mycobacterium tuberculosis transmission in a South African clinic: Spatiotemporal model based on person movements.PLoS computational biology · 2025Article
- Within-country heterogeneity in patterns of social contact relevant for tuberculosis infection transmission, prevention, and care.PLOS global public health · 2025Article
- Qualitative system dynamics modelling to support the design and implementation of tuberculosis infection prevention and control measures in South African primary healthcare facilities.Health policy and planning · 2024Article
- Stigma relating to tuberculosis infection prevention and control implementation in rural health facilities in South Africa - a qualitative study outlining opportunities for mitigation.BMC global and public health · 2024Article
- Comparison of microscopic and xpert MTB diagnoses of presumptive mycobacteria tuberculosis infection: retrospective analysis of routine diagnosis at Cape Coast Teaching Hospital.BMC infectious diseases · 2024Article
- Tuberculin skin test surveys and the Annual Risk of Tuberculous Infection in school children in Northern KwaZulu-Natal.PLOS global public health · 2024Article
- Cost-effectiveness of tuberculosis infection prevention and control interventions in South African clinics: a model-based economic evaluation informed by complexity science methods.BMJ global health · 2023Article
- Time to change the way we think about tuberculosis infection prevention and control in health facilities: insights from recent research.Antimicrobial stewardship & healthcare epidemiology : ASHE · 2023Article
- Healthcare seeking patterns for TB symptoms: Findings from the first national TB prevalence survey of South Africa, 2017-2019.PloS one · 2023Article
- Direct estimates of absolute ventilation and estimated Mycobacterium tuberculosis transmission risk in clinics in South Africa.PLOS global public health · 2022Article
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Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundThere is a high risk of
methodsWe developed an individual-based model of
resultsWe estimate that 7.6% (plausible range 3.9%-13.9%) of non-multidrug resistant and multidrug resistant TB in adults resulted directly from transmission in PHC clinics in the community in 2019. The proportion is higher in HIV-positive people, at 9.3% (4.8%-16.8%), compared with 5.3% (2.7%-10.1%) in HIV-negative people. We estimate that IPC interventions could reduce incident TB cases in the community in 2021-2030 by 3.4%-8.0%, and deaths by 3.0%-7.2%.
conclusionsA non-trivial proportion of TB results from transmission in clinics in the study community, particularly in HIV-positive people. Implementing IPC interventions could lead to moderate reductions in disease burden. We recommend that IPC measures in clinics should be implemented for their benefits to staff and patients, but also for their likely effects on TB incidence and mortality in the surrounding community.
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