Evidence map›Paper›PMID 35395948›Full record

ReviewStem cell research & therapy2022

Application of exosomes in the diagnosis and treatment of pancreatic diseases.

Li Han, Zhirong Zhao, Ke Yang, Mei Xin, Lichen Zhou, Siping Chen, Shibo Zhou, Zheng Tang, Hua Ji, Ruiwu Dai

Open access · goldAbstract readReview
In one paragraph

Review in Stem cell research & therapy, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 27 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Li Han *General Surgery Center, General Hospital of Western Theater Command, Chengdu, 610083, Sichuan Province, China.
Zhirong Zhao *College of Medicine, Southwest Jiaotong University, Chengdu, 610031, China.
Ke Yang *General Surgery Center, General Hospital of Western Theater Command, Chengdu, 610083, Sichuan Province, China.
Mei XinGeneral Surgery Center, General Hospital of Western Theater Command, Chengdu, 610083, Sichuan Province, China.
Lichen ZhouGeneral Surgery Center, General Hospital of Western Theater Command, Chengdu, 610083, Sichuan Province, China.
Siping ChenGeneral Surgery Center, General Hospital of Western Theater Command, Chengdu, 610083, Sichuan Province, China.
Shibo ZhouGeneral Surgery Center, General Hospital of Western Theater Command, Chengdu, 610083, Sichuan Province, China.
Zheng TangGeneral Surgery Center, General Hospital of Western Theater Command, Chengdu, 610083, Sichuan Province, China.
Hua JiGeneral Surgery Center, General Hospital of Western Theater Command, Chengdu, 610083, Sichuan Province, China.
Ruiwu DaiGeneral Surgery Center, General Hospital of Western Theater Command, Chengdu, 610083, Sichuan Province, China. dairuiwu@swjtu.edu.cn.ORCID 0000-0002-5487-135X
Southwest Medical University · CNChengdu Military General Hospital · CNSouthwest Jiaotong University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pancreatic diseases, a serious threat to human health, have garnered considerable research interest, as they are associated with a high mortality rate. However, owing to the uncertain etiology and complex pathophysiology, the treatment of pancreatic diseases is a challenge for clinicians and researchers. Exosomes, carriers of intercellular communication signals, play an important role in the diagnosis and treatment of pancreatic diseases. Exosomes are involved in multiple stages of pancreatic disease development, including apoptosis, immune regulation, angiogenesis, cell migration, and cell proliferation. Thus, extensive alterations in the quantity and variety of exosomes may be indicative of abnormal biological behaviors of pancreatic cells. This phenomenon could be exploited for the development of exosomes as a new biomarker or target of new treatment strategies. Several studies have demonstrated the diagnostic and therapeutic effects of exosomes in cancer and inflammatory pancreatic diseases. Herein, we introduce the roles of exosomes in the diagnosis and treatment of pancreatic diseases and discuss directions for future research and perspectives of their applications.

Indexed as

ExosomesPancreatic DiseasesPancreatic NeoplasmsCell CommunicationHumansPancreasAngiogenesisApoptosisCell migration and proliferationDiagnosisExosomeImmune regulationPancreatic disease

Identifiers

PMID35395948
PMCPMC8994331
OpenAlexW4223635802

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.