ArticleBMC endocrine disorders2022
Obesity is associated with subclinical hypothyroidism in the presence of thyroid autoantibodies: a cross-sectional study.
Article in BMC endocrine disorders, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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24 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.
- Prevalence and Levels of Thyroid Autoantibodies in Polycystic Ovary Syndrome-Impact of TSH- and BMI-Matched Comparisons: A Systematic Review and Meta-Analysis.International journal of molecular sciences · 2025Pooled it
- Association between childhood obesity and thyroid function: a cross-sectional study in a Chinese population.BMC public health · 2026Article
- Population-based national incidence of thyroid dysfunction in Spain.Scientific reports · 2025Observational
- Incidence of Subclinical Hypothyroidism in Obese Adults and Its Metabolic Implications: A Prospective Cohort Study.Cureus · 2025Article
- Nutrition and Micronutrient Interactions in Autoimmune Thyroid Disorders: Implications for Cardiovascular Health.Pathophysiology : the official journal of the International Society for Pathophysiology · 2025Review
- The impact of weight loss interventions on thyroid function: a systematic review and meta-analysis.Annals of medicine and surgery (2012) · 2025Review
- Estimation of kidney function in Graves' disease using creatinine and cystatin C.Endocrine connections · 2025Article
- Prevalence and Risk Factors of Obesity Among Type 2 Diabetic Participants in Abha, Saudi Arabia: A Cross-Sectional Study.Healthcare (Basel, Switzerland) · 2025Article
- Increased Serum Lipopolysaccharide Levels are Related to a Higher Prevalent Risk of Subclinical Hypothyroidism.International journal of endocrinology · 2025Article
- Endocrine and metabolic comorbidities in juvenile-onset systemic lupus erythematosus.Frontiers in medicine · 2025Article
- Association of thyroid hormone sensitivity indicators with visceral fat area in euthyroid overweight/obese type 2 diabetes patients: sex differences.Frontiers in endocrinology · 2025Article
- Thyroid dysfunction in heart failure with preserved ejection fraction: A systematic review and meta-analysis.ARYA atherosclerosis · 2025Review
- Weight Loss Programs: Why Do They Fail? A Multidimensional Approach for Obesity Management.Current nutrition reports · 2024Review
- Article
- Impact of methimazole-induced hypothyroidism on postnatal swine.Physiological reports · 2024Article
- Association between weight-adjusted waist index and Hashimoto's thyroiditis: insights from NHANES 2007-2012.Frontiers in nutrition · 2024Article
- Interactions between Polygenetic Variants and Lifestyle Factors in Hypothyroidism: A Hospital-Based Cohort Study.Nutrients · 2023Article
- Subclinical Hypothyroidism among Patients with COVID-19 Infection in a Tertiary Care Centre: A Descriptive Cross-sectional Study.JNMA; journal of the Nepal Medical Association · 2023Article
- Article
- Polycystic ovary syndrome and thyroid disorder: a comprehensive narrative review of the literature.Frontiers in endocrinology · 2023Review
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Authors and funding
13 authors at 2 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundBoth obesity and subclinical hypothyroidism (SCH) have adverse effects on human body, but the relationship between these two conditions remains inconsistent. The presence of thyroid autoantibodies influences thyroid hormone levels, and may further mediate the interaction between obesity and SCH. This study aimed to explore the association among obesity, SCH and thyroid autoantibodies.
methodsThis study was a cross-sectional survey of 2505 subjects. Obesity was defined as a body mass index ≥28 kg/m
resultsA proportion of 11.54% (289/2505) subjects were obese, and 165 subjects had SCH. The positive rates of thyroid autoantibodies, TPO-Ab and Tg-Ab were 17.64% (442/2505), 11.02% (276/2505) and 14.13% (354/2505), respectively. The proportion of SCH was significantly higher in obese than nonobese subjects among those with positive thyroid autoantibodies [22.41% (13/58) vs. 11.72% (45/384), p = 0.025, χ2 test]. Moreover, obesity was significantly associated with SCH in the presence of thyroid autoantibodies after adjusting for confounding factors (OR 2.212, 95% CI 1.103 to 4.433, p = 0.025). A higher proportion of subjects with obesity had Tg-Ab positivity [17.99% (52/289) vs. 13.63% (302/2216), p = 0.045, χ2 test], and obesity remained significantly associated with Tg-Ab positivity by multiple logistic analysis (OR 1.504, 95% CI 1.077 to 2.101, p = 0.017).
conclusionsObesity was associated with SCH in the presence of thyroid autoantibodies. Examination of SCH is recommended in obese subjects with thyroid autoantibody positivity.
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