Evidence map›Paper›PMID 35395780›Full record

ArticleClinical epigenetics2022

Epigenetics of early-life adversity in youth: cross-sectional and longitudinal associations.

Jennifer A Sumner, Simone Gambazza, Xu Gao, Andrea A Baccarelli, Monica Uddin, Katie A McLaughlin

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical epigenetics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 4 pooled it
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 4 syntheses or guidelines pooled it, 18 citations in OpenAlex.

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  6. Predictors of adolescent psychiatric rehospitalization: A multi-level framework.International journal of nursing studies advances · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 6 institutions in 3 countries.

Jennifer A SumnerDepartment of Psychology, University of California, Los Angeles, Psychology Building 1285, Box 951563, Los Angeles, CA, 90095-1563, USA. jsumner@psych.ucla.edu.
Simone GambazzaDepartment of Clinical Sciences and Community Health, University of Milan, Milan, Italy.
Xu GaoDepartment of Environmental Health Sciences, Columbia Mailman School of Public Health, New York, NY, USA.
Andrea A BaccarelliDepartment of Environmental Health Sciences, Columbia Mailman School of Public Health, New York, NY, USA.
Monica UddinGenomics Program, College of Public Health, University of South Florida, Tampa, FL, USA.
Katie A McLaughlinDepartment of Psychology, Harvard University, Cambridge, MA, USA.
Columbia University · USHarvard University · USPeking University · CNUniversity of California, Los Angeles · USUniversity of Milan · ITUniversity of South Florida · US

Funding

Neurodevelopmental Mechanisms Underlying Stress Vulnerability during AdolescenceR37MH119194 · NIMH · HARVARD UNIVERSITY · PI Katie McLaughlin · 2020 to 2026
$10.6M
Child Trauma and the Development of Neural Systems Underlying Emotion RegulationR01MH103291 · NIMH · UNIVERSITY OF WASHINGTON · PI MCLAUGHLIN, KATIE · 2014 to 2018
$3.8M
NIMH NIH HHS R01 MH103291NIMH NIH HHS R37 MH119194
6 · The paper itself

Abstract

backgroundAltered DNA methylation (DNAm) may be one pathway through which early-life adversity (ELA) contributes to adverse mental and physical health outcomes. This study investigated whether the presence versus absence of ELA experiences reflecting the dimensions of threat and deprivation were associated with epigenome-wide DNAm cross-sectionally and longitudinally in a community-based sample of children and adolescents.

methodsIn 113 youths aged 8-16 years with wide variability in ELA, we examined associations of abuse (physical, sexual, emotional; indicating threat-related experiences) and neglect (emotional, physical; indicating deprivation-related experiences) with DNAm assessed with the Illumina EPIC BeadChip array, with DNA derived from saliva. In cross-sectional epigenome-wide analyses, we investigated associations of lifetime abuse and neglect with DNAm at baseline. In longitudinal epigenome-wide analyses, we examined whether experiencing abuse and neglect over an approximately 2-year follow-up were each associated with change in DNAm from baseline to follow-up.

resultsIn cross-sectional analyses adjusting for lifetime experience of neglect, lifetime experience of abuse was associated with DNAm for four cytosine-phosphodiester-guanine (CpG) sites (cg20241299: coefficient = 0.023, SE = 0.004; cg08671764: coefficient = 0.018, SE = 0.003; cg27152686: coefficient = - 0.069, SE = 0.012; cg24241897: coefficient = - 0.003, SE = 0.001; FDR < .05). In longitudinal analyses, experiencing neglect over follow-up was associated with an increase in DNAm for one CpG site, adjusting for abuse over follow-up (cg03135983: coefficient = 0.036, SE = 0.006; FDR < .05).

conclusionsIn this study, we identified examples of epigenetic patterns associated with ELA experiences of threat and deprivation that were already observable in youth. We provide novel evidence for change in DNAm over time in relation to ongoing adversity and that experiences reflecting distinct ELA dimensions may be characterized by unique epigenetic patterns.

Indexed as

Adverse Childhood ExperiencesAdolescentChildCross-Sectional StudiesDNA MethylationEpigenesis, GeneticEpigenomicsHumansAbuseDeprivationDNA methylationNeglectThreat

Identifiers

PMID35395780
PMCPMC8994405
OpenAlexW4223583428

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.