Evidence map›Paper›PMID 35395739›Full record

ArticleBMC ophthalmology2022

Analysis on short-term change of macular function and the correlates after intravitreal conbercept for CRVO-ME.

Yun-Chang Wang, Rong-Rong Li, Yi Cai, Zi-Yi Wei, Chang-Liang Shao

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Article in BMC ophthalmology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Yun-Chang WangThe Key Laboratory of Ocular of Heibei Province, The Treatment Centre of Ocular Disease of Hebei Province, Heibei Eye Hospital, Number 399 quan bei dong da jie, Xingtai, 054001, Hebei Province, China. wycocular@163.com.
Rong-Rong LiThe Key Laboratory of Ocular of Heibei Province, The Treatment Centre of Ocular Disease of Hebei Province, Heibei Eye Hospital, Number 399 quan bei dong da jie, Xingtai, 054001, Hebei Province, China.
Yi CaiThe Key Laboratory of Ocular of Heibei Province, The Treatment Centre of Ocular Disease of Hebei Province, Heibei Eye Hospital, Number 399 quan bei dong da jie, Xingtai, 054001, Hebei Province, China.
Zi-Yi WeiThe Key Laboratory of Ocular of Heibei Province, The Treatment Centre of Ocular Disease of Hebei Province, Heibei Eye Hospital, Number 399 quan bei dong da jie, Xingtai, 054001, Hebei Province, China.
Chang-Liang ShaoThe Key Laboratory of Ocular of Heibei Province, The Treatment Centre of Ocular Disease of Hebei Province, Heibei Eye Hospital, Number 399 quan bei dong da jie, Xingtai, 054001, Hebei Province, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimTo study the short-term change of macular function and the correlates after intravitreal conbercept for CRVO-ME. STUDY

designProspective, clinical study.

methodsTwenty Three patients(23 eyes) were recruited, who were non-ischemia central retinal vein occlusion diagnosed by FFA (fundus fluorescein angiography) and treated with intravitreal conbercept for macular edema, best - corrected visual acuity ( BCVA), central macular thickness(CMT), amplitude density of P1 wave and implicit time of P1,N1 wave from ring 1 and ring 2 of mf-ERG were measured before and 1 week、2 month after treatment.

resultsCompared to the baseline, BCVA、CMT、amplitude density of P1 wave and implicit time of P1,N1 wave from ring 1 and ring 2 were greatly improved at 1 W、2 M after treatment; better results were gained at 2 M compared to 1 W; Pearson correlation analysis shows no significantly correlation between the improvement of mf-ERG with the change of BCVA、CMT.

conclusionThe BCVA、the structure and the function of macular were greatly improved after intravitreal conbercept for central retinal vein occlusion induced macular edema; however no significantly correlation between the improvement of the function of macular with the strcture of macular and BCVA.

Indexed as

Macular EdemaRetinal Vein OcclusionAngiogenesis InhibitorsFluorescein AngiographyHumansIntravitreal InjectionsProspective StudiesRecombinant Fusion ProteinsTomography, Optical CoherenceTreatment OutcomeVisual AcuityAngiogenesis InhibitorsKH902 fusion proteinRecombinant Fusion ProteinsConberceptMacular edemaMultifocal electroretinogramNon-ischemia central retinal vein occlusionOptical coherence tomography

Identifiers

PMID35395739
PMCPMC8994389

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