Evidence map›Paper›PMID 35395547›Full record

ReviewCurrent opinion in neurobiology2022

Role of the endoplasmic reticulum in synaptic transmission.

Natali L Chanaday, Ege T Kavalali

Open access · greenAbstract readReview
In one paragraph

Review in Current opinion in neurobiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 31 citations in OpenAlex.

  1. Immune-mediated excitotoxicity in brain disorders.Nature reviews. Immunology · 2026
    Review
  2. Review
  3. ER discontinuities are common inbioRxiv : the preprint server for biology · 2026
    Article
  4. Review
  5. Review
  6. Review
  7. Bltp1 Is Required for Survival and Normal Development and Function of the Neuromuscular Junction in Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article
  8. Review
  9. The Endoplasmic Reticulum and Its Contacts: Emerging Roles in Axon Development, Neurotransmission, and Degeneration.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2024
    Review
  10. Article
  11. Review
  12. Nano-organization of synaptic calcium signaling.Biochemical Society transactions · 2024
    Review
  13. Article
  14. Article
  15. Review
  16. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Natali L ChanadayDepartment of Pharmacology, School of Medicine, Vanderbilt University, Nashville, TN, 37240-7933, USA. Electronic address: natali.chanaday@vanderbilt.edu.
Ege T KavalaliDepartment of Pharmacology, School of Medicine, Vanderbilt University, Nashville, TN, 37240-7933, USA; Vanderbilt Brain Institute, Vanderbilt University, Nashville, TN, 37240-7933, USA. Electronic address: ege.kavalali@vanderbilt.edu.
Vanderbilt University · US

Funding

Role of SNARE Interactions in Central Synapse FunctionR01MH066198 · NIMH · VANDERBILT UNIVERSITY · PI KAVALALI, EGE T · 2004 to 2023
$7.9M
Calcium signaling and synaptic maintenance in Alzheimers diseaseRF1AG055577 · NIA · UT SOUTHWESTERN MEDICAL CENTER · PI BEZPROZVANNY, ILYA B, KAVALALI, EGE T · 2017 to 2017
$3.0M
NIA NIH HHS RF1 AG055577NIMH NIH HHS R01 MH066198
6 · The paper itself

Abstract

Neurons possess a complex morphology spanning long distances and a large number of subcellular specializations such as presynaptic terminals and dendritic spines. This structural complexity is essential for maintenance of synaptic junctions and associated electrical as well as biochemical signaling events. Given the structural and functional complexity of neurons, neuronal endoplasmic reticulum is emerging as a key regulator of neuronal function, in particular synaptic signaling. Neuronal endoplasmic reticulum mediates calcium signaling, calcium and lipid homeostasis, vesicular trafficking, and proteostasis events that underlie autonomous functions of numerous subcellular compartments. However, based on its geometric complexity spanning the whole neuron, endoplasmic reticulum also integrates the activity of these autonomous compartments across the neuron and coordinates their interactions with the soma. In this article, we review recent work regarding neuronal endoplasmic reticulum function and its relationship to neurotransmission and plasticity.

Indexed as

Endoplasmic ReticulumSynaptic TransmissionCalciumCalcium SignalingNeuronal PlasticityNeuronsSynapsesCalcium

Identifiers

PMID35395547
PMCPMC9167765
OpenAlexW4223631056

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.