Evidence map›Paper›PMID 35395503›Full record

ArticleDrug and alcohol dependence2022

Epigenome-wide association analyses of active injection drug use.

Chang Shu, Andrew E Jaffe, Sarven Sabunciyan, Hongkai Ji, Jacquie Astemborski, Jing Sun, Kelly M Bakulski, David W Sosnowski, Shruti H Mehta, Gregory D Kirk and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Drug and alcohol dependence, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.0field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Epigenetic age acceleration and mortality among persons with poorly controlled HIV.The journals of gerontology. Series A, Biological sciences and medical sciences · 2026
    Article
  3. Article
  4. Forensic genetics in the omics era.Nature reviews. Genetics · 2026
    Review
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Chang ShuDepartment of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA; Department of Pediatrics, Columbia University Irving Medical Center, New York, NY, USA.
Andrew E JaffeDepartment of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA; Lieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD, USA; Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Sarven SabunciyanDepartment of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Hongkai JiDepartment of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Jacquie AstemborskiDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Jing SunDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Kelly M BakulskiDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.
David W SosnowskiDepartment of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Shruti H MehtaDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Gregory D KirkDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Brion S MaherDepartment of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA. Electronic address: brion@jhu.edu.
Johns Hopkins University · USJohns Hopkins Medicine · USUniversity of Michigan–Ann Arbor · US

Funding

The AIDS Linked to the Intravenous Experience (ALIVE) StudyU01DA036297 · NIDA · JOHNS HOPKINS UNIVERSITY · PI Gregory D Kirk, Shruti H Mehta · 2014 to 2026
$28.9M
NIDA Epidemiology Training Program: Johns Hopkins UniversityT32DA007292 · NIDA · JOHNS HOPKINS UNIVERSITY · PI RENEE M. JOHNSON, Brion S Maher · 1993 to 2026
$17.7M
Pharmacogenomics of ART adherence and effectiveness in the ALIVE CohortR01DA047064 · NIDA · JOHNS HOPKINS UNIVERSITY · PI KIRK, GREGORY D, MAHER, BRION S · 2018 to 2023
$5.8M
Functional Genomics and Epigenomics in HIV of Longitudinal Injection Drug Use TrajectoryR01DA039408 · NIDA · JOHNS HOPKINS UNIVERSITY · PI MAHER, BRION S · 2015 to 2019
$3.1M
Patient-Oriented Research and Mentorship in HIV and Non-Communicable DiseasesK24AI118591 · NIAID · JOHNS HOPKINS UNIVERSITY · PI KIRK, GREGORY D · 2015 to 2019
$766k
NIAID NIH HHS K24 AI118591NIDA NIH HHS R01 DA039408NIDA NIH HHS R01 DA047064NIDA NIH HHS T32 DA007292NIDA NIH HHS U01 DA036297
6 · The paper itself

Abstract

backgroundInjection drug use (IDU) is prevalent in the US and is associated with substantial risk of blood-borne infections, morbidity, and mortality. However, the spectrum of its biologic effects on DNA methylation in blood is not well characterized.

methods401 participants (M

resultsWe found epigenome-wide significant CpG sites associated with active injection (cg10636246, AIM2, p = 2.33 × 10

conclusionsFindings from this study demonstrate modest, common, and specific effects on DNA methylation during a relatively short time between periods of active drug injection and abstinence.

Indexed as

EpigenomeGenome-Wide Association StudySubstance-Related DisordersCohort StudiesCpG IslandsDNA MethylationEpigenesis, GeneticFemaleHumansMaleMiddle AgedCocaineDNA methylationEpigeneticsHeroinInjection drug use

Identifiers

PMID35395503
PMCPMC13254627
OpenAlexW4221064533

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.