Evidence map›Paper›PMID 35395152›Full record

ArticleNature2022

Phage anti-CBASS and anti-Pycsar nucleases subvert bacterial immunity.

Samuel J Hobbs, Tanita Wein, Allen Lu, Benjamin R Morehouse, Julia Schnabel, Azita Leavitt, Erez Yirmiya, Rotem Sorek, Philip J Kranzusch

Open access · hybridAbstract read
In one paragraph

Article in Nature, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 113 papers.

0numbers the graph read from it
0cells of the map it votes in
113citing papers in PubMed
28.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

113 citing papers in PubMed, 179 citations in OpenAlex.

  1. Molecular control of bacterial immunity.Nature structural & molecular biology · 2026
    Review
  2. Article
  3. Article
  4. How bacterial immune systems sense phage infection.Nature reviews. Microbiology · 2026
    Review
  5. Revisiting the life cycle of temperate phages.Nature reviews. Microbiology · 2026
    Review
  6. Characterization of defensome genes and mobile genetic Elements in different types of pasture soil agroecosystems from the Brazilian Amazon.International microbiology : the official journal of the Spanish Society for Microbiology · 2026
    Article
  7. Article
  8. Review
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Review
  18. Article
  19. Phage RyR-domain proteins degrade ADPR-based immune signals and fuel NADbioRxiv : the preprint server for biology · 2026
    Article
  20. Article

53 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Samuel J HobbsDepartment of Microbiology, Harvard Medical School, Boston, MA, USA.
Tanita WeinDepartment of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel.
Allen LuDepartment of Microbiology, Harvard Medical School, Boston, MA, USA.
Benjamin R MorehouseDepartment of Microbiology, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0003-3352-5463
Julia SchnabelDepartment of Microbiology, Harvard Medical School, Boston, MA, USA.
Azita LeavittDepartment of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel.
Erez YirmiyaDepartment of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel.
Rotem SorekDepartment of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel.ORCID http://orcid.org/0000-0002-3872-4982
Philip J KranzuschDepartment of Microbiology, Harvard Medical School, Boston, MA, USA. philip_kranzusch@dfci.harvard.edu.ORCID http://orcid.org/0000-0002-4943-733X
Harvard University · USWeizmann Institute of Science · IL

Funding

User Training and OutreachP30GM124165 · NIGMS · CORNELL UNIVERSITY · PI STEVEN E EALICK · 2018 to 2026
$34.2M
Discovery of cGAS-like signaling enzymes in innate immunity and diseaseDP2GM146250 · NIGMS · DANA-FARBER CANCER INST · PI KRANZUSCH, PHILIP J · 2021 to 2024
$2.5M
Pixel Array Detector for Macromolecular CrystallographyS10OD021527 · OD · CORNELL UNIVERSITY · PI EALICK, STEVEN E · 2016 to 2016
$2.0M
Pixel Array Detector for X-ray CrystallographyS10RR029205 · NCRR · CORNELL UNIVERSITY · PI EALICK, STEVEN E · 2010 to 2010
$1.8M
Mechanism of activation of a new cGAS-like enzyme in humansF32GM133063 · NIGMS · DANA-FARBER CANCER INST · PI MOREHOUSE, BENJAMIN ROBERT · 2019 to 2020
$127k
European Research CouncilNCRR NIH HHS S10 RR029205NIGMS NIH HHS DP2 GM146250NIGMS NIH HHS F32 GM133063NIGMS NIH HHS P30 GM124165NIH HHS S10 OD021527
6 · The paper itself

Abstract

The cyclic oligonucleotide-based antiphage signalling system (CBASS) and the pyrimidine cyclase system for antiphage resistance (Pycsar) are antiphage defence systems in diverse bacteria that use cyclic nucleotide signals to induce cell death and prevent viral propagation

Indexed as

BacteriophagesBacteriaBacterial ProteinsBacteriophage T4CRISPR-Cas SystemsEndonucleasesEscherichia coliNucleotides, CyclicOligonucleotidesPyrimidinesBacterial ProteinsEndonucleasesNucleotides, CyclicOligonucleotidesPyrimidines

Identifiers

PMID35395152
PMCPMC9117128
OpenAlexW4223506823

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.