Evidence map›Paper›PMID 35395120›Full record

ArticleActa paediatrica (Oslo, Norway : 1992)2022

National cohort of infants born before 24 gestational weeks showed increased survival rates but no improvement in neonatal morbidity.

Pia Lundgren, Eva Morsing, Anna-Lena Hård, Alexander Rakow, Lena Hellström-Westas, Lena Jacobson, Mats Johnson, Gerd Holmström, Staffan Nilsson, Lois E Smith and 2 more

Open access · bronzeAbstract read
In one paragraph

Article in Acta paediatrica (Oslo, Norway : 1992), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
4.7field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 31 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 7 institutions in 2 countries.

Pia LundgrenThe Sahlgrenska Centre for Pediatric Ophthalmology Research, Department of Clinical Neuroscience, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.ORCID 0000-0002-7731-1988
Eva MorsingDepartment of Pediatrics, Clinical Sciences Lund, Lund University, Lund, Sweden.ORCID 0000-0001-6871-6070
Anna-Lena HårdThe Sahlgrenska Centre for Pediatric Ophthalmology Research, Department of Clinical Neuroscience, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.ORCID 0000-0002-2440-2851
Alexander RakowDepartment of Women's and Children's Health, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden.
Lena Hellström-WestasDepartment of Women's and Children's Health, Uppsala University, Uppsala, Sweden.ORCID 0000-0003-3498-6069
Lena JacobsonThe Sahlgrenska Centre for Pediatric Ophthalmology Research, Department of Clinical Neuroscience, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.ORCID 0000-0001-8563-2127
Mats JohnsonGillberg Neuropsychiatry Centre, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Gerd HolmströmDepartment of Surgical Sciences/Ophthalmology, Uppsala University, Uppsala, Sweden.
Staffan NilssonMathematical Sciences, Chalmers University of Technology, Gothenburg, Sweden.
Lois E SmithDepartment of Ophthalmology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Karin SävmanRegion Västra Götaland, Department of Neonatology, The Queen Silvia Children´s Hospital, Sahlgrenska University Hospital, Gothenburg, Sweden.
Ann HellströmThe Sahlgrenska Centre for Pediatric Ophthalmology Research, Department of Clinical Neuroscience, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.ORCID 0000-0002-9259-1244
Sahlgrenska University Hospital · SEKarolinska University Hospital · SEUppsala University · SEBoston Children's Hospital · USChalmers University of Technology · SELund University · SEUniversity of Gothenburg · SE

Funding

Dietary control of angiogenesis in retinopathy modelsR01EY017017 · NEI · BOSTON CHILDREN'S HOSPITAL · PI Zhongjie Fu, Lois Smith · 2006 to 2026
$11.8M
Genetic Analysis and Manipulation Core (GAEC)P50HD105351 · NICHD · BOSTON CHILDREN'S HOSPITAL · PI Hisashi Umemori · 2021 to 2026
$9.4M
Mouse Neurodevelopmental Behavior CoreU54HD090255 · NICHD · BOSTON CHILDREN'S HOSPITAL · PI WOOLF, CLIFFORD J · 2016 to 2020
$5.2M
Glucose/lipid metabolism and vessel development in phase I ROPR01EY030904 · NEI · BOSTON CHILDREN'S HOSPITAL · PI SMITH, LOIS · 2020 to 2023
$1.7M
NEI NIH HHS R01 EY017017NEI NIH HHS R01 EY030904NICHD NIH HHS P50 HD105351NICHD NIH HHS U54 HD090255NIH HHS EY017017NIH HHS EY030904
6 · The paper itself

Abstract

aimTo describe survival and neonatal morbidities in infants born before 24 weeks of gestation during a 12-year period.

methodsData were retrieved from national registries and validated in medical files of infants born before 24 weeks of gestation 2007-2018 in Sweden. Temporal changes were evaluated.

resultsIn 2007-2018, 282 live births were recorded at 22 weeks and 460 at 23 weeks of gestation. Survival to discharge from hospital of infants born alive at 22 and 23 weeks increased from 20% to 38% (p = 0.006) and from 45% to 67% (p < 0.001) respectively. Caesarean section increased from 12% to 22% (p = 0.038) for infants born at 22 weeks. Neonatal morbidity rates in infants alive at 40 weeks of postmenstrual age (n = 399) were unchanged except for an increase in necrotising enterocolitis from 0 to 33% (p = 0.017) in infants born at 22 weeks of gestation. Bronchopulmonary dysplasia was more common in boys than girls, 90% versus 82% (p = 0.044). The number of infants surviving to 40 weeks doubled over time.

conclusionIncreased survival of infants born before 24 weeks of gestation resulted in increasing numbers of very immature infants with severe neonatal morbidities likely to have a negative impact on long-term outcome.

Indexed as

Infant MortalityInfant, Premature, DiseasesCesarean SectionFemaleGestational AgeHumansInfantInfant, Extremely PrematureInfant, NewbornMaleMorbidityPregnancySurvival Rateextremely pretermnecrotising enterocolitisneonatal morbiditiesproactive approachsurvival rates

Identifiers

PMID35395120
PMCPMC9454067
OpenAlexW4223469934

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.