Evidence map›Paper›PMID 35395096›Full record

ArticleEpilepsia2022

Ambient air pollution and epileptic seizures: A panel study in Australia.

Zhuying Chen, Wenhua Yu, Rongbin Xu, Philippa J Karoly, Matias I Maturana, Daniel E Payne, Lyra Li, Ewan S Nurse, Dean R Freestone, Shanshan Li and 4 more

Open access · hybridAbstract read
In one paragraph

Article in Epilepsia, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
3.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 29 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 1 country.

Zhuying ChenDepartment of Biomedical Engineering, The University of Melbourne, Melbourne, Victoria, Australia.ORCID 0000-0002-0997-2004
Wenhua YuSchool of Public Health and Preventive Medicine, Monash University, Clayton, Victoria, Australia.ORCID 0000-0002-4733-8610
Rongbin XuSchool of Public Health and Preventive Medicine, Monash University, Clayton, Victoria, Australia.
Philippa J KarolyDepartment of Biomedical Engineering, The University of Melbourne, Melbourne, Victoria, Australia.ORCID 0000-0002-9879-5854
Matias I MaturanaDepartment of Medicine, St Vincent's Hospital, The University of Melbourne, Melbourne, Victoria, Australia.
Daniel E PayneDepartment of Biomedical Engineering, The University of Melbourne, Melbourne, Victoria, Australia.ORCID 0000-0002-8608-0253
Lyra LiGraeme Clark Institute, The University of Melbourne, Melbourne, Victoria, Australia.
Ewan S NurseDepartment of Medicine, St Vincent's Hospital, The University of Melbourne, Melbourne, Victoria, Australia.ORCID 0000-0001-8981-0074
Dean R FreestoneSeer Medical, Melbourne, Victoria, Australia.
Shanshan LiSchool of Public Health and Preventive Medicine, Monash University, Clayton, Victoria, Australia.
Anthony N BurkittDepartment of Biomedical Engineering, The University of Melbourne, Melbourne, Victoria, Australia.
Mark J CookDepartment of Biomedical Engineering, The University of Melbourne, Melbourne, Victoria, Australia.
Yuming GuoSchool of Public Health and Preventive Medicine, Monash University, Clayton, Victoria, Australia.ORCID 0000-0002-1766-6592
David B GraydenDepartment of Biomedical Engineering, The University of Melbourne, Melbourne, Victoria, Australia.ORCID 0000-0002-5497-7234
The University of Melbourne · AUMonash University · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveEmerging evidence has shown that ambient air pollution affects brain health, but little is known about its effect on epileptic seizures. This work aimed to assess the association between daily exposure to ambient air pollution and the risk of epileptic seizures.

methodsThis study used epileptic seizure data from two independent data sources (NeuroVista and Seer App seizure diary). In the NeuroVista data set, 3273 seizures were recorded using intracranial electroencephalography (iEEG) from 15 participants with refractory focal epilepsy in Australia in 2010-2012. In the seizure diary data set, 3419 self-reported seizures were collected through a mobile application from 34 participants with epilepsy in Australia in 2018-2021. Daily average concentrations of carbon monoxide (CO), nitrogen dioxide (NO

resultsA significant association between CO concentrations and epileptic seizure risks was observed, with an increased seizure risk of 4% (relative risk [RR]: 1.04, 95% confidence interval [CI]: 1.01-1.07) for an interquartile range (IQR) increase of CO concentrations (0.13 parts per million), whereas no significant associations were found for the other four air pollutants in the whole study population. Female participants had a significantly increased risk of seizures when exposed to elevated CO and NO SIGNIFICANCE: Daily exposure to elevated CO concentrations may be associated with an increased risk of epileptic seizures, especially for subclinical seizures.

Indexed as

Air PollutantsAir PollutionEpilepsies, PartialEpilepsyAustraliaFemaleHumansNitrogen DioxideSeizuresAir PollutantsNitrogen Dioxideair pollutionAustraliacase-crossover designepilepsyseizures

Identifiers

PMID35395096
PMCPMC9543609
OpenAlexW4223541111

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.