Evidence map›Paper›PMID 35395041›Full record

ArticlePloS one2022

Liver stiffness as surrogate parameter in emergency assessment for inpatient health care utilization.

Dominic Kaddu-Mulindwa, Marius von Martial, Angela Thiel-Bodenstaff, Vadim Lesan, Sebastian Ewen, Felix Mahfoud, Frank Lammert, Marcin Krawczyk

Open access · goldAbstract read
In one paragraph

Article in PloS one, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 52% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Dominic Kaddu-MulindwaDepartment of Medicine I, Saarland University Medical Center, Saarland University, Homburg, Germany.ORCID 0000-0001-8832-252X
Marius von MartialDepartment of Medicine II, Saarland University Medical Center, Saarland University, Homburg, Germany.
Angela Thiel-BodenstaffDepartment of Medicine II, Saarland University Medical Center, Saarland University, Homburg, Germany.
Vadim LesanDepartment of Medicine I, Saarland University Medical Center, Saarland University, Homburg, Germany.
Sebastian EwenDepartment of Medicine III, Saarland University Medical Center, Saarland University, Homburg, Germany.
Felix MahfoudDepartment of Medicine III, Saarland University Medical Center, Saarland University, Homburg, Germany.
Frank LammertDepartment of Medicine II, Saarland University Medical Center, Saarland University, Homburg, Germany.
Marcin KrawczykDepartment of Medicine II, Saarland University Medical Center, Saarland University, Homburg, Germany.ORCID 0000-0002-0113-0777
Saarland University · DEMedical University of Warsaw · PLMedizinische Hochschule Hannover · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTransient elastography (TE) allows non-invasive quantification of liver stiffness (LSM) and steatosis (controlled attenuation parameter, CAP). Here we test the feasibility and utility of TE in the emergency department (ED) and investigate whether LSM predicts longer hospitalization and reimbursement for non-elective patients.

methodsLSM and CAP were determined in prospectively recruited consecutive adult patients admitted to the ED of a tertiary referral center. Patients were stratified according to the 9.1 kPa and 13.0 kPa LSM cut-offs. Elastography measurements were correlated with clinical and outcome parameters, including duration of hospital stay and hospitalization costs.

resultsIn 200 ED patients (133 men, age 18 - 97 years), median LSM was 5.5 kPa (2.4 - 69.1 kPa), and median CAP was 252 dB/m (100 - 400 dB/m). In total, 39 patients (19.5%) presented with LSM ≥ 9.1 kPa, and 24 patients (12.0%) presented with LSM ≥ 13.0 kPa. Heart failure (n = 19) was associated with higher LSM (p = 0.045). Patients with LSM ≥ 9.1 kPa were significantly (p < 0.01) more likely to require longer hospitalization than those with lower LSM. Patients with LSM ≥ 13.0 kPa generated significantly (p = 0.001) higher costs as compared to patients with low LSM.

conclusionsTransient elastography represents an easily accessible screening tool in ED that might help identify patients in need of increased health care resources.

Indexed as

Elasticity Imaging TechniquesInpatientsAdolescentAdultAgedAged, 80 and overHumansLiverLiver CirrhosisMaleMiddle AgedPatient Acceptance of Health CareYoung Adult

Identifiers

PMID35395041
PMCPMC8992973
OpenAlexW4225603620

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.