ReviewComparative immunology, microbiology and infectious diseases1986
Effects of immunopotentiating agents on alveolar macrophage properties.
Review in Comparative immunology, microbiology and infectious diseases, 1986. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed.
- Study of the potential involvement of pseudorabies virus in swine respiratory disease.Canadian journal of veterinary research = Revue canadienne de recherche veterinaire · 1992Article
- Rationale for using immunopotentiators in domestic food animals.Advances in veterinary science and comparative medicine · 1990Review
- Activated porcine alveolar macrophages: are biological response modifiers the answer?Veterinary immunology and immunopathology · 1989Article
- Interactions of Pseudorabies virus with swine alveolar macrophages I: virus replication.Archives of virology · 1989Article
Corrections and comments
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Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Infectious respiratory diseases in man and in domestic animals are characterized by the presence of a large number of different microorganisms: viruses, bacterias, mycoplasmas. It is therefore necessary to stimulate non-specific defense mechanisms in the lung and especially alveolar macrophages (AM). These cells, located in the alveolar air-spaces, play a major role in the lung clearance mechanisms and exert antibacterial, antiviral and antitumoral activities. Activation of alveolar macrophages was studied in vitro with lipopolysaccharide (LPS), lymphokines or mycobacterial derivatives (MDP). Rodent alveolar macrophages were rendered cytotoxic by in vitro exposure to LPS, free MDP or liposome-encapsulated MDP derivatives. In vivo, intravenously administered liposomes containing lipophilic MDP derivatives induced cytotoxic alveolar macrophages and protected mice against the development of pulmonary metastases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.