ArticleProceedings of the National Academy of Sciences of the United States of America2022
In situ optical spectroscopy of crystallization: One crystal nucleation at a time.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14 citing papers in PubMed.
- Molecular Extraction and Release of an Ionic Liquid Microdroplet With Dynamic Tunability Under Optical Trapping.Chemphyschem : a European journal of chemical physics and physical chemistry · 2026Article
- Extra-large pore JZO zeolites with tunable Si/Al ratios as efficient catalysts for degradable plastic monomer production.RSC advances · 2026Article
- In Situ Online Spectroscopy and Light Scattering Techniques.Advances in biochemical engineering/biotechnology · 2026Review
- Design Principles Of Inorganic-Protein Hybrid Materials for Biomedicine.Exploration (Beijing, China) · 2025Review
- Enhanced polymorph metastability drives glycine nucleation in aqueous salt solutions.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- The effect of salt additives on the glycine crystallization pathway revealed by studying one crystal nucleation at a time.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Photo-Assisted Bottom-Up Synthesis of Orange Phosphorus.Angewandte Chemie (International ed. in English) · 2025Article
- A Review of Laser-Induced Crystallization from Solution.Crystal growth & design · 2023Review
- Driving and characterizing nucleation of urea and glycine polymorphs in water.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Cinematographic Recording of a Metastable Floating Island in Two- and Three-Dimensional Crystal Growth.ACS central science · 2022Article
- Crystallization of SrAlThe journal of physical chemistry. C, Nanomaterials and interfaces · 2022Article
- Mesoscopic amorphous particles rather than oligomeric molecular aggregates are the cause of laser-induced crystal nucleation.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Reply to Liao and Wynne: The size of crystal nucleus remains an open question.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Crystal nucleation: Rare made common and captured by Raman.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
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5 authors.
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No grant is acknowledged in the PubMed record.
Abstract
While crystallization is a ubiquitous and an important process, the microscopic picture of crystal nucleation is yet to be established. Recent studies suggest that the nucleation process can be more complex than the view offered by the classical nucleation theory. Here, we implement single crystal nucleation spectroscopy (SCNS) by combining Raman microspectroscopy and optical trapping induced crystallization to spectroscopically investigate one crystal nucleation at a time. Raman spectral evolution during a single glycine crystal nucleation from water, measured by SCNS and analyzed by a nonsupervised spectral decomposition technique, uncovered the Raman spectrum of prenucleation aggregates and their critical role as an intermediate species in the dynamics. The agreement between the spectral feature of prenucleation aggregates and our simulation suggests that their structural order emerges through the dynamic formation of linear hydrogen-bonded networks. The present work provides a strong impetus for accelerating the investigation of crystal nucleation by optical spectroscopy.
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