ArticleProceedings of the National Academy of Sciences of the United States of America2022
Origin and early evolution of the plant terpene synthase family.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 112 papers.
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112 citing papers in PubMed, 178 citations in OpenAlex.
- Review
- Tandem duplication underlies diversification of the gymnosperm-specific TPS-d subfamily.Horticulture research · 2026Article
- Deciphering genetic basis of phenylethanoid glycoside production through integrative multiomics analysis inHorticulture research · 2026Article
- Insight into TPS-d Subfamily: The Evolutionary and Functional Diversity in Gymnosperms.Biomolecules · 2026Review
- Genomic mechanism of aroma terpenoids biosynthesis in plants.Journal of advanced research · 2026Review
- Terpenoids fromPlants (Basel, Switzerland) · 2026Review
- Divergent Lineage of Terpene Synthases Establishes Terpenoid Biosynthesis in Brown Macroalgae.Journal of the American Chemical Society · 2026Article
- Article
- Molecular evolution of terpene synthase underlying the diversification of isoprene emission in Fagaceae.Plant biology (Stuttgart, Germany) · 2026Article
- Rhizophagus irregularis modulates neighbour-primed defences in Medicago truncatula against foliar pathogens via common mycelial network-mediated inter-plant signals.Communications biology · 2026Article
- A Review of Plant-Derived Diterpenoid Biosynthesis: From Structural Scaffold Diversity and Lineage-Associated Distribution to Enzyme Mining and Discovery Strategies.Molecules (Basel, Switzerland) · 2026Review
- The earliest amber from the Middle Devonian of China.Science advances · 2026Article
- Comprehensive genomic analysis reveals the class II diterpene cyclases in Dodonaea viscosa.Phytochemistry · 2026Article
- Deciphering flavonoids and terpenoids biosynthesis through chromosomal-level genome, metabolome, and transcriptome integration inHorticulture research · 2026Article
- Genetic blueprint of herbaceous peony floral scent: evidence from terpene synthase, Nudix hydrolase, and prenyltransferase.Horticulture research · 2026Article
- PAGD: the Persea americana Genome Database and a Docker-based transcriptome analysis workflow.BMC genomics · 2026Article
- Neofunctionalization underlies the evolutionary origin of sclareol biosynthesis in the mint family.Nature communications · 2026Article
- Peeking behind the carbocation: identification of (alternative) catalytic bases in the class II active site of conifer resin acid diterpene synthases.The Biochemical journal · 2026Article
- Structural diversity of isoprene synthases in mosses from multiple terpenoid synthase lineages.The Journal of biological chemistry · 2026Article
- High Terpene Production in Myrtaceae: Evolutionary Insights from Terpene Pathway Genes.Plants (Basel, Switzerland) · 2026Article
52 more citing papers are in PubMed but not listed here.
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9 authors at 5 institutions in 4 countries.
Funding
Abstract
As a midsized gene family conserved more by lineage than function, the typical plant terpene synthases (TPSs) could be a valuable tool to examine plant evolution. TPSs are pivotal in biosynthesis of gibberellins and related phytohormones as well as in formation of the extensive arsenal of specialized plant metabolites mediating ecological interactions whose production is often lineage specific. Yet the origin and early evolution of the TPS family is not well understood. Systematic analysis of an array of transcriptomes and sequenced genomes indicated that the TPS family originated after the divergence of land plants from charophytic algae. Phylogenetic and biochemical analyses support the hypothesis that the ancestral TPS gene encoded a bifunctional class I and II diterpene synthase producing the ent-kaurene required for phytohormone production in all extant lineages of land plants. Moreover, the ancestral TPS gene likely underwent duplication at least twice early in land plant evolution. Together these two gave rise to three TPS lineages leading to the extant TPS-c, TPS-e/f, and the remaining TPS (h/d/a/b/g) subfamilies, with the latter dedicated to secondary rather than primary metabolism while the former two contain those genes involved in ent-kaurene production. Nevertheless, parallel evolution from the ent-kaurene–producing class I and class II diterpene synthases has led to roles for TPS-e/f and -c subfamily members in secondary metabolism as well. These results clarify TPS evolutionary history and provide context for the role of these genes in producing the vast diversity of terpenoid natural products observed today in various land plant lineages.
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