Evidence map›Paper›PMID 35394679›Full record

ArticleMolecular nutrition & food research2022

A Screening of Native (Poly)phenols and Gut-Related Metabolites on 3D HCT116 Spheroids Reveals Gut Health Benefits of a Flavan-3-ol Metabolite.

Josep Rubert, Pamela Gatto, Michael Pancher, Viktoryia Sidarovich, Claudio Curti, Pedro Mena, Daniele Del Rio, Alessandro Quattrone, Fulvio Mattivi

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular nutrition & food research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 20 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Josep RubertFood Quality and Design, Wageningen University & Research, Bornse Weilanden 9, Wageningen, 6708 WG, The Netherlands.ORCID 0000-0002-1634-2334
Pamela GattoHTS and Validation Core Facility, Dept. CIBIO - Department of Cellular, Computational and Integrative Biology, University of Trento, Via Sommarive 9, Trento, 38123, Italy.
Michael PancherHTS and Validation Core Facility, Dept. CIBIO - Department of Cellular, Computational and Integrative Biology, University of Trento, Via Sommarive 9, Trento, 38123, Italy.
Viktoryia SidarovichHTS and Validation Core Facility, Dept. CIBIO - Department of Cellular, Computational and Integrative Biology, University of Trento, Via Sommarive 9, Trento, 38123, Italy.
Claudio CurtiDepartment of Food and Drug, University of Parma, Parco Area delle Scienze, 27/A, Parma, 43124, Italy.
Pedro MenaHuman Nutrition Unit, Department of Food and Drug, University of Parma, Medical School Building C, Via Volturno, 39, Parma, 43125, Italy.ORCID 0000-0003-2150-2977
Daniele Del RioHuman Nutrition Unit, Department of Food and Drug, University of Parma, Medical School Building C, Via Volturno, 39, Parma, 43125, Italy.ORCID 0000-0001-5394-1259
Alessandro QuattroneLaboratory of Translational Genomics, Dept. CIBIO - Department of Cellular, Computational and Integrative Biology, University of Trento, Via Sommarive 9, Trento, 38123, Italy.
Fulvio MattiviDept. CIBIO - Department of Cellular, Computational and Integrative Biology, University of Trento, Via Sommarive 9, Trento, 38123, Italy.
University of Trento · ITUniversity of Parma · ITFondazione Edmund Mach · ITWageningen University & Research · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

scopeEpidemiological evidence suggests that a reduced risk of colorectal cancer (CRC) is correlated with high consumption of fruits and vegetables, which are major sources of fiber and phytochemicals, such as flavan-3-ols. However, it remains unknown how these phytochemicals and their specific gut-related metabolites may alter cancer cell behavior. METHODS AND

resultsA focused screening using native (poly)phenols and gut microbial metabolites (GMMs) on 3D HCT116 spheroids is carried out using a high-throughput imaging approach. Dose-responses, IC

conclusionA chronic exposure to (4R)-5-(3',4'-dihydroxyphenyl)-γ-valerolactone may lead to a reduced CRC risk. Daily intake of monomeric, oligomeric, and polymeric flavan-3-ols may increase the colonic concentrations of this metabolite, and, in turn, this compound may act locally interacting with intestinal epithelial cells, precancerous and cancer cells.

Indexed as

Gastrointestinal MicrobiomePhenolsFlavonoidsLactonesPolyphenolsflavan-3-olFlavonoidsgamma-valerolactoneLactonesPhenolsPolyphenols3D spheroidscolorectal cancerflavan-3-olsgut microbial metaboliteshigh content imaging

Identifiers

PMID35394679
PMCPMC9787721
OpenAlexW4224252245

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.