Evidence map›Paper›PMID 35394639›Full record

ArticleMolecular and cellular biochemistry2022

Methionine restriction enhances the chemotherapeutic sensitivity of colorectal cancer stem cells by miR-320d/c-Myc axis.

Chuan Liu, Jin-Liang Wang, Deng-Zhong Wu, Yi-Wu Yuan, Lin Xin

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular and cellular biochemistry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.3field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 17 citations in OpenAlex.

  1. The metabolic profiles of cancer stem cells.Stem cell research & therapy · 2026
    Review
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  13. The Role of Tumor Stem Cells in Colorectal Cancer Drug Resistance.Cancer control : journal of the Moffitt Cancer Center
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Chuan LiuJiangxi Key Laboratory of Molecular Medicine, The Second Affiliated Hospital of Nanchang University, Nanchang, 330006, Jiangxi Province, China.
Jin-Liang WangDepartment of General Surgery, The Second Affiliated Hospital of Nanchang University, No. 1 Minde Road, Donghu District, Nanchang, 330006, Jiangxi Province, China.
Deng-Zhong WuDepartment of General Surgery, The Second Affiliated Hospital of Nanchang University, No. 1 Minde Road, Donghu District, Nanchang, 330006, Jiangxi Province, China.
Yi-Wu YuanDepartment of General Surgery, The Second Affiliated Hospital of Nanchang University, No. 1 Minde Road, Donghu District, Nanchang, 330006, Jiangxi Province, China.
Lin XinDepartment of General Surgery, The Second Affiliated Hospital of Nanchang University, No. 1 Minde Road, Donghu District, Nanchang, 330006, Jiangxi Province, China. xinlindoc@hotmail.com.ORCID http://orcid.org/0000-0002-2553-4450
Nanchang University · CN

Funding

Jiangxi Province Academic and Technical Leaders Training Program for Major Disciplines Nos. 20213BCJ22014Key Research and Development Program of Jiangxi Province Nos. 20203BBG73056Province Natural Science Foundation of Jiangxi Nos. 20192BAB205079The National Natural Science Foundation of China Nos. 8216100399
6 · The paper itself

Abstract

Chemotherapy resistance of colorectal cancer stem cells (CRC-SCs) has become a major challenge in clinical treatment of cancer. Methionine restriction (MR) enhances the therapeutic effect of chemotherapeutic agents. The aim of this study was to explore the molecular pathways that MR affects the chemotherapeutic sensitivity of CRC-SCs. CD133

Indexed as

Colorectal NeoplasmsMicroRNAsAnimalsCell Line, TumorCell ProliferationDrug Resistance, NeoplasmFluorouracilGene Expression Regulation, NeoplasticHumansMethionineMiceNeoplastic Stem CellsFluorouracilMethionineMicroRNAsChemotherapeutic sensitivityc-MycColorectal cancer stem cellsMethionine restrictionmiR-320d

Identifiers

PMID35394639
OpenAlexW4226343915

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.