Evidence map›Paper›PMID 35394617›Full record

ArticleBrain imaging and behavior2022

Effects of Mild Traumatic Brain Injury on Resting State Brain Network Connectivity in Older Adults.

Mayra Bittencourt, Harm-Jan van der Horn, Sebastián A Balart-Sánchez, Jan-Bernard C Marsman, Joukje van der Naalt, Natasha M Maurits

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain imaging and behavior, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
0.8field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Mayra BittencourtDepartment of Neurology, University of Groningen, University Medical Center Groningen (UMCG), Groningen, The Netherlands. m.bittencourt.villalpando@umcg.nl.ORCID http://orcid.org/0000-0001-5248-9272
Harm-Jan van der HornDepartment of Neurology, University of Groningen, University Medical Center Groningen (UMCG), Groningen, The Netherlands.
Sebastián A Balart-SánchezDepartment of Neurology, University of Groningen, University Medical Center Groningen (UMCG), Groningen, The Netherlands.
Jan-Bernard C MarsmanDepartment of Biomedical Sciences of Cells and Systems, University of Groningen, University Medical Center Groningen, Cognitive Neuroscience Center, Groningen, The Netherlands.
Joukje van der NaaltDepartment of Neurology, University of Groningen, University Medical Center Groningen (UMCG), Groningen, The Netherlands.
Natasha M MauritsDepartment of Neurology, University of Groningen, University Medical Center Groningen (UMCG), Groningen, The Netherlands.
University Medical Center Groningen · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Older age is associated with worsened outcome after mild traumatic brain injury (mTBI) and a higher risk of developing persistent post-traumatic complaints. However, the effects of mTBI sequelae on brain connectivity at older age and their association with post-traumatic complaints remain understudied.We analyzed multi-echo resting-state functional magnetic resonance imaging data from 25 older adults with mTBI (mean age: 68 years, SD: 5 years) in the subacute phase (mean injury to scan interval: 38 days, SD: 9 days) and 20 age-matched controls. Severity of complaints (e.g. fatigue, dizziness) was assessed using self-reported questionnaires. Group independent component analysis was used to identify intrinsic connectivity networks (ICNs). The effects of group and severity of complaints on ICNs were assessed using spatial maps intensity (SMI) as a measure of within-network connectivity, and (static) functional network connectivity (FNC) as a measure of between-network connectivity.Patients indicated a higher total severity of complaints than controls. Regarding SMI measures, we observed hyperconnectivity in left-mid temporal gyrus (cognitive-language network) and hypoconnectivity in the right-fusiform gyrus (visual-cerebellar network) that were associated with group. Additionally, we found interaction effects for SMI between severity of complaints and group in the visual(-cerebellar) domain. Regarding FNC measures, no significant effects were found.In older adults, changes in cognitive-language and visual(-cerebellar) networks are related to mTBI. Additionally, group-dependent associations between connectivity within visual(-cerebellar) networks and severity of complaints might indicate post-injury (mal)adaptive mechanisms, which could partly explain post-traumatic complaints (such as dizziness and balance disorders) that are common in older adults during the subacute phase.

Indexed as

Brain ConcussionAgedBrainDizzinessHumansMagnetic Resonance ImagingNerve NetAgingBrain connectivityFusiform gyrusMild traumatic brain injuryPost-concussive symptoms

Identifiers

PMID35394617
PMCPMC9279274
OpenAlexW4225728536

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.