ArticleeLife2022
Endogenous
Open access · goldAbstract read
In one paragraph
Article in eLife, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 27 citations in OpenAlex.
- The Synaptic Clock: SynGAP1 as a Molecular Timer of Postsynaptic Density Consolidation.Biomolecules · 2026Review
- Syngap1 Synchronizes Relative Neuronal Maturation Across Cortical Areas to Organize Distributed Functional Networks.bioRxiv : the preprint server for biology · 2026Article
- Disruption of the SYNGAP1 PDZ ligand motif accelerates differentiation of human iPSC-derived GABAergic neurons.bioRxiv : the preprint server for biology · 2026Article
- The "cutting edge" of non-canonical RNA splicing.Frontiers in molecular biosciences · 2026Review
- The Endo-GeneScreen platform identifies drug-like probes that regulate endogenous protein levels within physiological contexts.Nature communications · 2025Article
- AAV delivery of full-length SYNGAP1 rescues epileptic and behavioral phenotypes in a mouse model of SYNGAP1-related disorders.Molecular therapy : the journal of the American Society of Gene Therapy · 2025Article
- Syngap1 promotes cognitive function through regulation of cortical sensorimotor dynamics.Nature communications · 2025Article
- DevelopmentalThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Article
- Review
- Proximity analysis of native proteomes reveals phenotypic modifiers in a mouse model of autism and related neurodevelopmental conditions.Nature communications · 2024Article
- Context-dependent hyperactivity inFrontiers in molecular neuroscience · 2024Article
- Unveiling a de novoSAGE open medical case reports · 2024Article
- Non-synaptic function of the autism spectrum disorder-associated gene SYNGAP1 in cortical neurogenesis.Nature neuroscience · 2023Article
- Phenotype and genotype analyses of Chinese patients with autosomal dominant mental retardation type 5 caused byFrontiers in genetics · 2022Article
- Proteomics and weighted gene correlated network analysis reveal glutamatergic synapse signaling in diazepam treatment of alcohol withdrawal.Frontiers in pharmacology · 2022Article
- Some (Syn)Gaps are Worse than Others: Deciphering The Role of Syngap Isoforms in Excitatory Synaptic Function.Epilepsy currentsArticle
- Research progress inFrontiers in neurologyReview
- Roadmap to advance therapeutics forTherapeutic advances in rare diseaseReview
Corrections and comments
- Commented on by
Authors and funding
17 authors at 4 institutions in 3 countries.
Murat KilincGraduate School of Chemical and Biological Sciences, The Scripps Research Institute, Jupiter, United States.ORCID 0000-0003-0928-7573
Vineet AroraDepartments of Neuroscience and Molecular Medicine, The Scripps Research Institute, Jupiter, United States.ORCID 0000-0001-7856-0401
Thomas K CresonDepartments of Neuroscience and Molecular Medicine, The Scripps Research Institute, Jupiter, United States.
Camilo RojasDepartments of Neuroscience and Molecular Medicine, The Scripps Research Institute, Jupiter, United States.
Aliza A LeDepartment of Anatomy and Neurobiology, The University of California, Irvine, United States.
Julie LauterbornDepartment of Anatomy and Neurobiology, The University of California, Irvine, United States.
Brent WilkinsonZilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California, Los Angeles, United States.
Nicolas HartelMork Family Department of Chemical Engineering and Materials Science, University of Southern California, Los Angeles, United States.
Nicholas GrahamMork Family Department of Chemical Engineering and Materials Science, University of Southern California, Los Angeles, United States.
Adrian ReichBioinformatics and Statistics Core, The Scripps Research Institute, Jupiter, United States.
Gemma GouMolecular Physiology of the Synapse Laboratory, Institut d'Investigació Biomèdica Sant Pau, Barcelona, Spain.
Yoichi ArakiDepartment of Neuroscience, Johns Hopkins School of Medicine, Baltimore, United States.ORCID 0000-0002-3455-9377
Àlex BayésMolecular Physiology of the Synapse Laboratory, Institut d'Investigació Biomèdica Sant Pau, Barcelona, Spain.ORCID 0000-0002-5265-6306
Marcelo CobaZilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California, Los Angeles, United States.
Gary LynchDepartment of Anatomy and Neurobiology, The University of California, Irvine, United States.
Courtney A MillerGraduate School of Chemical and Biological Sciences, The Scripps Research Institute, Jupiter, United States.
Gavin RumbaughGraduate School of Chemical and Biological Sciences, The Scripps Research Institute, Jupiter, United States.ORCID 0000-0001-6360-3894
Scripps Research Institute · USUniversity of Southern California · USInstitut d'Investigació Biomédica de Bellvitge · ESUniversitat Autònoma de Barcelona · ES
Funding
Intersection of causal neurodevelopmental disorder risk genes, cortical circuit function, and cognitive processing required for behavioral adaptionsR01MH096847 · NIMH · UNIVERSITY OF FLORIDA · PI Courtney A Miller, GAVIN R RUMBAUGH · 2012 to 2026
$10.4MRegulation of Memory Formation by the GTPase-activating Protein SynGAPR01NS064079 · NINDS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI RUMBAUGH, GAVIN R · 2009 to 2017
$3.9MEvaluation of novel biomarkers of cognition in a model of sporadic developmental brain disorders and their application in efficacy testing of Ras pathway inhibitorsR01MH108408 · NIMH · SCRIPPS FLORIDA · PI RUMBAUGH, GAVIN R · 2015 to 2019
$3.3MRegulation of postsynaptic protein interaction networks in complex brain disordersR01MH115005 · NIMH · UNIVERSITY OF SOUTHERN CALIFORNIA · PI COBA, MARCELO PABLO · 2018 to 2022
$2.9MSynaptic actin dynamics and the selective vulnerability of drug-associated memoryR01DA034116 · NIDA · SCRIPPS FLORIDA · PI MILLER, COURTNEY A · 2013 to 2018
$2.8MCharacterization of SynGAP Mutations in Human Cognitive DisordersR01MH112151 · NIMH · JOHNS HOPKINS UNIVERSITY · PI HUGANIR, RICHARD L · 2017 to 2021
$2.7MCausal Interactions between genetic risk, precise cortical connectivity, and autism-associated behaviorsR01NS110307 · NINDS · UNIVERSITY OF FLORIDA · PI RUMBAUGH, GAVIN R · 2020 to 2024
$2.6MMiRNA-mediated mechanisms of long-term traumatic and non-traumatic memory storageR01MH105400 · NIMH · SCRIPPS FLORIDA · PI MILLER, COURTNEY A · 2015 to 2019
$2.5MLoss and rescue of endocannabinoid-dependent LTP and memory in Fragile-X model miceR01HD089491 · NICHD · UNIVERSITY OF CALIFORNIA-IRVINE · PI GALL, CHRISTINE M, LYNCH, GARY S · 2016 to 2020
$2.2MTraining Program in Learning and MemoryT32MH119049 · NIMH · UNIVERSITY OF CALIFORNIA-IRVINE · PI BRUCE L MCNAUGHTON, Manuella Yassa · 2019 to 2026
$1.4MNeurodevelopmental impact of prenatal exposure to prescription pain medicationR21DA036376 · NIDA · SCRIPPS FLORIDA · PI MILLER, COURTNEY A · 2014 to 2015
$473kRegulation of PSD phosphorylation and protein interactions networks by LTPR21MH113949 · NIMH · UNIVERSITY OF SOUTHERN CALIFORNIA · PI COBA, MARCELO PABLO · 2017 to 2018
$437kNICHD NIH HHS R01 HD089491NIDA NIH HHS R01 DA034116NIDA NIH HHS R21 DA036376NIMH NIH HHS R01 MH096847NIMH NIH HHS R01 MH105400NIMH NIH HHS R01 MH108408NIMH NIH HHS R01 MH112151NIMH NIH HHS R01 MH115005NIMH NIH HHS R21 MH113949NIMH NIH HHS T32 MH119049NINDS NIH HHS R01 NS064079NINDS NIH HHS R01 NS110307
Abstract
Loss-of-function variants in
Indexed as
ras GTPase-Activating ProteinsSeizuresAnimalsCognitionMiceMutationProtein IsoformsSynapsesProtein Isoformsras GTPase-Activating ProteinsSyngap1 protein, mousebehaviorcognitionisoformsmouseneuroscienceseizuresplicingSyngap1
Identifiers
What OpenQuestion holds
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LicenceCC BY
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.