Evidence map›Paper›PMID 35394167›Full record

ArticlePediatric surgery international2022

Factors influencing the development of Multicystic Dysplastic Kidney (MCDK) following urinary tract obstruction in the fetal lamb.

Yuri Nishiya, Kohei Kawaguchi, Kosuke Kudo, Takuya Kawaguchi, Juma Obayashi, Kunihide Tanaka, Kei Ohyama, Shigeyuki Furuta, Yasuji Seki, Junki Koike and 2 more

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Article in Pediatric surgery international, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.1field-weighted citation impact, top 59% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 2 countries.

Yuri NishiyaDivision of Pediatric Surgery, School of Medicine, St. Marianna University, 2-16-1, Sugao, Miyamae-ku, Kawasaki, Kanagawa, Japan, 216-8511.
Kohei KawaguchiDivision of Pediatric Surgery, School of Medicine, St. Marianna University, 2-16-1, Sugao, Miyamae-ku, Kawasaki, Kanagawa, Japan, 216-8511.
Kosuke KudoDivision of Pediatric Surgery, School of Medicine, St. Marianna University, 2-16-1, Sugao, Miyamae-ku, Kawasaki, Kanagawa, Japan, 216-8511.
Takuya KawaguchiDivision of Pediatric Surgery, School of Medicine, St. Marianna University, 2-16-1, Sugao, Miyamae-ku, Kawasaki, Kanagawa, Japan, 216-8511.
Juma ObayashiDivision of Pediatric Surgery, School of Medicine, St. Marianna University, 2-16-1, Sugao, Miyamae-ku, Kawasaki, Kanagawa, Japan, 216-8511.
Kunihide TanakaDivision of Pediatric Surgery, School of Medicine, St. Marianna University, 2-16-1, Sugao, Miyamae-ku, Kawasaki, Kanagawa, Japan, 216-8511.
Kei OhyamaDivision of Pediatric Surgery, School of Medicine, St. Marianna University, 2-16-1, Sugao, Miyamae-ku, Kawasaki, Kanagawa, Japan, 216-8511.
Shigeyuki FurutaDivision of Pediatric Surgery, School of Medicine, St. Marianna University, 2-16-1, Sugao, Miyamae-ku, Kawasaki, Kanagawa, Japan, 216-8511.
Yasuji SekiDivision of Pediatric Surgery, School of Medicine, St. Marianna University, 2-16-1, Sugao, Miyamae-ku, Kawasaki, Kanagawa, Japan, 216-8511.
Junki KoikeDepartment of Pathology, School of Medicine, St. Marianna University, 2-16-1, Sugao, Miyamae-ku, Kawasaki, Kanagawa, Japan, 216-8511.
Kevin C PringleDepartment of Obstetrics and Gynecology, University of Otago, Lambton Centre, 117 Lambton Quay, Wellington Central, Wellington, 6011, New Zealand.
Hiroaki KitagawaDivision of Pediatric Surgery, School of Medicine, St. Marianna University, 2-16-1, Sugao, Miyamae-ku, Kawasaki, Kanagawa, Japan, 216-8511. h2kita@marianna-u.ac.jp.ORCID http://orcid.org/0000-0002-7023-3745
St. Marianna University School of Medicine · JPUniversity of Otago · NZ

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCreating obstructive uropathy (OU) during glomerulogenesis in the fetal lamb results in multicystic dysplastic kidney (MCDK) at term. We explored this using immunohistochemical techniques.

methodOU was created in fetal lambs at 60-day gestation, ligating the urethra and urachus. The kidneys of MCDK lambs, 60-day gestation fetal lambs, full-term lamb (145 days), term sham-operated lambs, and adult ewes were evaluated by HE staining, and immunohistochemistry with paired box genes 2 (PAX2) and CD10.

resultsMultiple cysts were found in the MCDK model. CD10 was expressed in proximal tubular epithelial cells, glomerular epithelial cells, and medullary stromal cells in the kidneys of 60-day gestation fetal lambs and full-term lambs and adult ewes. PAX2 expression was found in ureteric buds, C- and S-shaped bodies, epithelial cells of collecting ducts, and Bowman's capsule of fetal kidneys at 60-day gestation, but only in the collecting ducts of full-term fetal lambs and adult ewes. Both CD10 and PAX2 were expressed in the cystic epithelial cells of the MCDK model. DISCUSSION: PAX2 expression in cystic epithelial cells suggests that cyst formation is associated with disturbed down-regulation of PAX2 in the nephrogenic zone epithelial cells during the renal development in the OU model.

Indexed as

Multicystic Dysplastic KidneyUrethral DiseasesAnimalsFemaleFetusHumansKidneyMaleSheepUrethraCD10KidneyMCDKMulticystic dysplastic kidneyPAX2

Identifiers

PMID35394167
OpenAlexW4225253198

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.