Evidence map›Paper›PMID 35394159›Full record

Trial reportPsychopharmacology2022

Comparison of TWA and PEP as indices of α2- and ß-adrenergic activation.

L Drost, J B Finke, J Port, H Schächinger

Abstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Psychopharmacology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

L DrostInstitute of Psychobiology, Department of Clinical Psychophysiology, University of Trier, Johanniterufer 15, 54290, Trier, Germany. s1lidros@uni-trier.de.
J B FinkeDepartment of Clinical Psychology, University of Siegen, Adolf-Reichwein-Str. 2a, 57076, Siegen, Germany.
J PortDepartment of Biomedical Technic, University of Stuttgart, Seidenstraße 36, 70174, Stuttgart, Germany.
H SchächingerInstitute of Psychobiology, Department of Clinical Psychophysiology, University of Trier, Johanniterufer 15, 54290, Trier, Germany.
Universität Trier · DEUniversity of Siegen · DEUniversity of Stuttgart · DE

Funding

Deutsche Forschungsgemeinschaft SCHA 12372-1
6 · The paper itself

Abstract

rationalePre-ejection period (PEP) and T-wave amplitude (TWA) have been used to assess sympathetic nervous system (SNS) activity. Here we report two single-blinded, placebo-controlled intravenous (IV) drug application studies in which we pharmacologically modified SNS activity with epinephrine (study 1) as well as dexmedetomidine (alpha2-agonist) and yohimbine (alpha2-antagonist) (study 2). Restricted heart rate (HR) intervals were analyzed to avoid confounding effects of HR changes.

objectiveStudy 1 served to replicate previous findings and to validate our approach, whereas study 2 aimed to investigate how modulation of central SNS activity affects PEP and TWA.

methodsForty healthy volunteers (58% females) participated in study 1 (between-subject design). Twelve healthy men participated in study 2 (within-subject design). TWA and PEP were derived from ECG and impedance cardiography, respectively.

resultsEpinephrine shortened PEP and induced statistically significant biphasic TWA changes. However, although the two alpha2-drugs significantly affected PEP as expected, no effects on TWA could be detected.

conclusionPEP is better suited to reflect SNS activity changes than TWA.

Indexed as

Adrenergic AgentsArrhythmias, CardiacEpinephrineFemaleHeart RateHumansMaleSympathetic Nervous SystemAdrenergic AgentsEpinephrineAlpha2-adrenoreceptorsBeta-adrenergic activationDexmedetomidinePre-ejection periodSympathetic nervous systemT-wave amplitudeYohimbine

Identifiers

PMID35394159
OpenAlexW4226190435

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.