Evidence map›Paper›PMID 35394038›Full record

Trial reportTransactions of the Royal Society of Tropical Medicine and Hygiene2022

The impact of Loa loa microfilaraemia on research subject retention during a whole sporozoite malaria vaccine trial in Equatorial Guinea.

Stephen R Manock, Vicente Urbano Nsue, Ally Olotu, Maximillian Mpina, Elizabeth Nyakarungu, José Raso, Ali Mtoro, Martín Eka Ondo Mangue, Beltrán Ekua Ntutumu Pasialo, Rufino Nguema and 8 more

Open access · hybridAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Transactions of the Royal Society of Tropical Medicine and Hygiene, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 5 institutions in 5 countries.

Stephen R ManockSanaria Inc., Rockville, MD 20850, USA.
Vicente Urbano NsueNational Malaria Control Program, Ministry of Health and Social Welfare, Malabo, Equatorial Guinea.
Ally OlotuDepartment of Interventions & Clinical Trials, Ifakara Health Institute, Box 74, Bagamoyo, Tanzania.
Maximillian MpinaDepartment of Interventions & Clinical Trials, Ifakara Health Institute, Box 74, Bagamoyo, Tanzania.
Elizabeth NyakarunguDepartment of Interventions & Clinical Trials, Ifakara Health Institute, Box 74, Bagamoyo, Tanzania.
José RasoNational Malaria Control Program, Ministry of Health and Social Welfare, Malabo, Equatorial Guinea.
Ali MtoroDepartment of Interventions & Clinical Trials, Ifakara Health Institute, Box 74, Bagamoyo, Tanzania.
Martín Eka Ondo MangueNational Malaria Control Program, Ministry of Health and Social Welfare, Malabo, Equatorial Guinea.
Beltrán Ekua Ntutumu PasialoNational Malaria Control Program, Ministry of Health and Social Welfare, Malabo, Equatorial Guinea.
Rufino NguemaNational Program for Onchocerciasis and Other Filariasis Control, Ministry of Health and Social Welfare, Malabo, Equatorial Guinea.
Pouria RiyahiSanaria Inc., Rockville, MD 20850, USA.
Tobias SchindlerDepartment of Medical Parasitology and Infection Biology, Clinical Immunology, Swiss Tropical and Public Health Institute, 4002 Basel, Switzerland.
Claudia DaubenbergerDepartment of Medical Parasitology and Infection Biology, Clinical Immunology, Swiss Tropical and Public Health Institute, 4002 Basel, Switzerland.
L W Preston ChurchSanaria Inc., Rockville, MD 20850, USA.
Peter F BillingsleySanaria Inc., Rockville, MD 20850, USA.
Thomas L RichieSanaria Inc., Rockville, MD 20850, USA.
Salim AbdullaDepartment of Interventions & Clinical Trials, Ifakara Health Institute, Box 74, Bagamoyo, Tanzania.
Stephen L HoffmanSanaria Inc., Rockville, MD 20850, USA.
National University of Equatorial Guinea · GQSanaria · USIfakara Health Institute · TZUniversity of Basel · CHJohn Peter Smith Hospital · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Loa loa microfilariae were found on thick blood smears (TBSs) from 8 of 300 (2.7%) residents of Bioko Island, Equatorial Guinea, during a Plasmodium falciparum sporozoite malaria vaccine clinical trial. Only one subject was found to have microfilaraemia on his first exam; parasites were not discovered in the other seven until subsequent TBSs were performed, at times many weeks into the study. All infected individuals were asymptomatic, and were offered treatment with diethylcarbamazine, per national guidelines. L. loa microfilaraemia complicated the enrolment or continued participation of these eight trial subjects, and only one was able to complete all study procedures. If ruling out loiasis is deemed to be important during clinical trials, tests that are more sensitive than TBSs should be performed.

Indexed as

Malaria, FalciparumMalaria VaccinesAnimalsEquatorial GuineaHumansLoaResearch SubjectsSporozoitesMalaria VaccinesLoa loaloiasismalaria vaccinemicrofilaraemiamicrofilaria

Identifiers

PMID35394038
PMCPMC9355999
OpenAlexW4225710734

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.