Evidence map›Paper›PMID 35393785›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2022

Wirelessly Activated Nanotherapeutics for In Vivo Programmable Photodynamic-Chemotherapy of Orthotopic Bladder Cancer.

Bowen Sun, Juwita Norasmara Bte Rahmat, Han Joon Kim, Ratha Mahendran, Kesavan Esuvaranathan, Edmund Chiong, John S Ho, Koon Gee Neoh, Yong Zhang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 41 citations in OpenAlex.

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  6. Sonogenetics in the Treatment of Chronic Diseases: A New Method for Cell Regulation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Bowen SunDepartment of Chemical and Biomolecular Engineering, College of Design and Engineering, National University of Singapore, Singapore, 117585, Singapore.
Juwita Norasmara Bte RahmatDepartment of Biomedical Engineering, College of Design and Engineering, National University of Singapore, Singapore, 117583, Singapore.ORCID 0000-0003-4134-0434
Han Joon KimDepartment of Electrical and Computer Engineering, College of Design and Engineering, National University of Singapore, Singapore, 117583, Singapore.
Ratha MahendranDepartment of Surgery, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 119228, Singapore.
Kesavan EsuvaranathanDepartment of Surgery, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 119228, Singapore.
Edmund ChiongDepartment of Surgery, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 119228, Singapore.
John S HoDepartment of Electrical and Computer Engineering, College of Design and Engineering, National University of Singapore, Singapore, 117583, Singapore.
Koon Gee NeohDepartment of Chemical and Biomolecular Engineering, College of Design and Engineering, National University of Singapore, Singapore, 117585, Singapore.
Yong ZhangDepartment of Biomedical Engineering, College of Design and Engineering, National University of Singapore, Singapore, 117583, Singapore.ORCID 0000-0002-1303-0458
National University of Singapore · SG

Funding

Ministry of Education of Singapore MOE 2016-T3-1-004Ministry of Education of Singapore R-397-000-274-112Ministry of Education of Singapore R-397-000-348-114Ministry of Education of Singapore R-397-000-375-114
6 · The paper itself

Abstract

Photochemical internalization (PCI) is a promising intervention using photodynamic therapy (PDT) to enhance the activity of chemotherapeutic drugs. However, current bladder cancer treatments involve high-dose chemotherapy and high-irradiance PDT which cause debilitating side effects. Moreover, low penetration of light and drugs in target tissues and cumbersome light delivery procedures hinder the clinical utility of PDT and chemotherapy combination for PCI. To circumvent these challenges, a photodynamic-chemotherapy approach is developed comprising tumor-targeting glycosylated nanocarriers, coloaded with chlorin e6 (Ce6) and gemcitabine elaidate (GemE), and a miniaturized implantable wirelessly powered light-emitting diode (LED) as a light source. The device successfully delivers four weekly light doses to the bladder while the nanocarrier promoted the specific accumulation of drugs in tumors. This approach facilitates the combination of low-irradiance PDT (1 mW cm

Indexed as

PhotochemotherapyUrinary Bladder NeoplasmsAnimalsCell Line, TumorMicePhotosensitizing AgentsPhotosensitizing Agentsbladder cancerphotodynamic therapytargeted drug deliverywireless photonics

Identifiers

PMID35393785
PMCPMC9165499
OpenAlexW4226232567

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.