ArticleHuman brain mapping2022
Age-related change in task-evoked amygdala-prefrontal circuitry: A multiverse approach with an accelerated longitudinal cohort aged 4-22 years.
Article in Human brain mapping, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Gamified Attention Bias Modification Training to Augment Cognitive Behavioral Therapy for Youth Anxiety Disorders: A Randomized Controlled Trial.Journal of the American Academy of Child and Adolescent Psychiatry · 2026Trial
- A Randomized Controlled Trial of a Parenting Intervention During Infancy Alters Amygdala-Prefrontal Circuitry in Middle Childhood.Journal of the American Academy of Child and Adolescent Psychiatry · 2024Trial
- AutoML-Multiverse: An Instability-Aware Framework for Quantifying Analytic Variability in Alzheimer's Disease Machine-Learning Studies.medRxiv : the preprint server for health sciences · 2026Article
- The effects of adverse life events on brain development in the ABCD study®: a propensity-weighted analysis.Molecular psychiatry · 2025Article
- Integrating data science and neuroscience in developmental psychopathology: Formative examples and future directions.Development and psychopathology · 2024Article
- Exposure to community violence as a mechanism linking neighborhood disadvantage to amygdala reactivity and the protective role of parental nurturance.Developmental psychology · 2024Article
- Leveraging the developmental neuroscience of caregiving to promote resilience among youth exposed to adversity.Development and psychopathology · 2023Article
- Exploring the multiverse: the impact of researchers' analytic decisions on relationships between depression and inflammatory markers.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023Article
- Differentiating Between Us & Them: Reduced In-Group Bias as a Novel Mechanism Linking Childhood Violence Exposure with Internalizing Psychopathology.Research on child and adolescent psychopathology · 2023Article
- Childhood trauma, earlier pubertal timing, and psychopathology in adolescence: The role of corticolimbic development.Developmental cognitive neuroscience · 2023Article
- Mediating effect of pubertal stages on the family environment and neurodevelopment: An open-data replication and multiverse analysis of an ABCD StudyNeuroimage. Reports · 2022Article
- Associations between early-life stress exposure and internalizing symptomatology during the COVID-19 pandemic: Assessing the role of neurobehavioral mediators.Biological psychiatry global open science · 2022Article
- Does pubertal stage mediate the association between family environment and structure and function of the amygdala-mPFC circuit? A replication study of the longitudinal ABCD cohort.Developmental cognitive neuroscience · 2022Article
- Accelerated pubertal development as a mechanism linking trauma exposure with depression and anxiety in adolescence.Current opinion in psychology · 2022Review
- Age-related change in task-evoked amygdala-prefrontal circuitry: A multiverse approach with an accelerated longitudinal cohort aged 4-22 years.Human brain mapping · 2022Article
- A guided multiverse study of neuroimaging analyses.Nature communications · 2022Article
- Neural heterogeneity underlying late adolescent motivational processing is linked to individual differences in behavioral sensation seeking.Journal of neuroscience research · 2022Article
Corrections and comments
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Authors and funding
15 authors.
Funding
Abstract
The amygdala and its connections with medial prefrontal cortex (mPFC) play central roles in the development of emotional processes. While several studies have suggested that this circuitry exhibits functional changes across the first two decades of life, findings have been mixed - perhaps resulting from differences in analytic choices across studies. Here we used multiverse analyses to examine the robustness of task-based amygdala-mPFC function findings to analytic choices within the context of an accelerated longitudinal design (4-22 years-old; N = 98; 183 scans; 1-3 scans/participant). Participants recruited from the greater Los Angeles area completed an event-related emotional face (fear, neutral) task. Parallel analyses varying in preprocessing and modeling choices found that age-related change estimates for amygdala reactivity were more robust than task-evoked amygdala-mPFC functional connectivity to varied analytical choices. Specification curves indicated evidence for age-related decreases in amygdala reactivity to faces, though within-participant changes in amygdala reactivity could not be differentiated from between-participant differences. In contrast, amygdala-mPFC functional connectivity results varied across methods much more, and evidence for age-related change in amygdala-mPFC connectivity was not consistent. Generalized psychophysiological interaction (gPPI) measurements of connectivity were especially sensitive to whether a deconvolution step was applied. Our findings demonstrate the importance of assessing the robustness of findings to analysis choices, although the age-related changes in our current work cannot be overinterpreted given low test-retest reliability. Together, these findings highlight both the challenges in estimating developmental change in longitudinal cohorts and the value of multiverse approaches in developmental neuroimaging for assessing robustness of results.
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