Evidence map›Paper›PMID 35393717›Full record

ArticleHuman brain mapping2022

Effective psychological therapy for PTSD changes the dynamics of specific large-scale brain networks.

Marina Charquero-Ballester, Birgit Kleim, Diego Vidaurre, Christian Ruff, Eloise Stark, Jetro J Tuulari, Hugh McManners, Yair Bar-Haim, Linda Bouquillon, Allison Moseley and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Human brain mapping, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 13 citations in OpenAlex.

  1. Functional brain imaging in posttraumatic stress disorder: a review.Journal of neural transmission (Vienna, Austria : 1996) · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 7 institutions in 4 countries.

Marina Charquero-BallesterDepartment of Psychiatry, University of Oxford, Oxford, UK.ORCID 0000-0001-6638-9862
Birgit KleimExperimental Psychopathology and Psychotherapy, Department of Psychology, University of Zurich, Zurich, Switzerland.
Diego VidaurreWellcome Trust Centre for Integrative NeuroImaging, Oxford Centre for Human Brain Activity (OHBA), University of Oxford, Oxford, UK.ORCID 0000-0002-9650-2229
Christian RuffZurich Center for Neuroeconomics (ZNE), Department of Economics, University of Zurich, Zurich, Switzerland.
Eloise StarkDepartment of Psychiatry, University of Oxford, Oxford, UK.
Jetro J TuulariDepartment of Psychiatry, University of Oxford, Oxford, UK.
Hugh McMannersScars of War Foundation, The Queen's College, Oxford, UK.
Yair Bar-HaimSchool of Psychological Sciences, Tel Aviv University, Tel Aviv, Israel.
Linda BouquillonDepartment of Psychology, Institute of Psychiatry, Psychology & Neurosciences, King's College London, London, UK.
Allison MoseleyDepartment of Psychology, Institute of Psychiatry, Psychology & Neurosciences, King's College London, London, UK.
Steven C R WilliamsDepartment of Neuroimaging, Institute of Psychiatry, Psychology & Neurosciences, King's College London, London, UK.
Mark W WoolrichWellcome Trust Centre for Integrative NeuroImaging, Oxford Centre for Human Brain Activity (OHBA), University of Oxford, Oxford, UK.
Morten L KringelbachDepartment of Psychiatry, University of Oxford, Oxford, UK.ORCID 0000-0002-3908-6898
Anke EhlersOxford Centre for Anxiety Disorders and Trauma, Department of Experimental Psychology, University of Oxford, Oxford, UK.
University of Oxford · GBKing's College London · GBUniversity of Zurich · CHAarhus University · DKOxford Health NHS Foundation Trust · GBTel Aviv University · ILThe Queen's Foundation · GB

Funding

Medical Research Council MR/K005464/1Wellcome Trust 069777Wellcome Trust 200796Wellcome Trust 200796/Z/16/Z
6 · The paper itself

Abstract

In posttraumatic stress disorder (PTSD), re-experiencing of the trauma is a hallmark symptom proposed to emerge from a de-contextualised trauma memory. Cognitive therapy for PTSD (CT-PTSD) addresses this de-contextualisation through different strategies. At the brain level, recent research suggests that the dynamics of specific large-scale brain networks play an essential role in both the healthy response to a threatening situation and the development of PTSD. However, very little is known about how these dynamics are altered in the disorder and rebalanced after treatment and successful recovery. Using a data-driven approach and fMRI, we detected recurring large-scale brain functional states with high temporal precision in a population of healthy trauma-exposed and PTSD participants before and after successful CT-PTSD. We estimated the total amount of time that each participant spent on each of the states while being exposed to trauma-related and neutral pictures. We found that PTSD participants spent less time on two default mode subnetworks involved in different forms of self-referential processing in contrast to PTSD participants after CT-PTSD (mtDMN

Indexed as

Memory, EpisodicStress Disorders, Post-TraumaticBrainBrain MappingHumansMagnetic Resonance ImagingCognitive behaviour therapyDefault mode networkfMRIHidden Markov ModelPTSD

Identifiers

PMID35393717
PMCPMC9188968
OpenAlexW4225552314

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.