ArticleNature genetics2022
Genetic variants underlying differences in facial morphology in East Asian and European populations.
Article in Nature genetics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 2 of them syntheses that pooled it.
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Who cites it
34 citing papers in PubMed, 2 syntheses or guidelines pooled it, 54 citations in OpenAlex.
- Multi-ancestry genome-wide association analyses of polycystic ovary syndrome.Nature genetics · 2025Pooled it
- The genetic architecture of hip shape and its role in the development of hip osteoarthritis and fracture.Human molecular genetics · 2025Pooled it
- A Facial Foundation Model for Clinical Biomarker Prediction and Real-World Mobile Deployment.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Atlas of cell types and regulatory elements underlying human facial diversity.Nature genetics · 2026Article
- Craniofacial features and pathogenic variants in 1,252 children with neurodevelopmental disorders.BMC pediatrics · 2026Article
- Large-scale human genomic resources drive innovations toward forensic intelligent source attribution and precision identification.International journal of legal medicine · 2026Review
- Revealing mandibular asymmetry in orthognathic surgery patients via Bonwill triangle morphology: a retrospective cross-sectional study.BMC oral health · 2026Article
- Ancestry estimation: Methodological evolution and forensic implications.Forensic science, medicine, and pathology · 2026Review
- Establishing standards for genome wide association studies in eusocial insects through a case study in honey bees.Scientific reports · 2026Article
- Glycine-GLRA1-calmodulin signaling regulates endoplasmic reticulum calcium to sustain insulin secretion and β-cell function.Life metabolism · 2026Article
- Rising Tide of Crustacean Allergies in East Asia: a Comprehensive Review of Genetic Insights and Implications for Early Evaluation of Health Risks.Clinical reviews in allergy & immunology · 2026Review
- Reply to "Comment on 'De Novo Reconstruction of 3D Human Facial Images From DNA Sequence'".Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Comment on "De Novo Reconstruction of 3D Human Facial Images from DNA Sequence".Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- The craniofacial shape of modern humans embodies genomic signatures of evolution, diversity, and clinical conditions.bioRxiv : the preprint server for biology · 2026Article
- Comparative study of fetal facial shape between Japanese and North American populations using micro-CT.Scientific reports · 2025Article
- Association ofInternational journal of molecular sciences · 2025Article
- De Novo Reconstruction of 3D Human Facial Images from DNA Sequence.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Combined genome-wide association study of facial traits in Europeans increases explained variance and improves prediction.Nature communications · 2025Article
- Baseline Plasma GPX3 Level Predicts Efficacy of Insulin-Sensitization Drug Chiglitazar in Type 2 Diabetes.Phenomics (Cham, Switzerland) · 2025Article
- 3D facial imaging: a novel approach for metabolic abnormalities risk profiling.Science China. Life sciences · 2025Article
Corrections and comments
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Authors and funding
19 authors at 5 institutions in 5 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Facial morphology-a conspicuous feature of human appearance-is highly heritable. Previous studies on the genetic basis of facial morphology were performed mainly in European-ancestry cohorts (EUR). Applying a data-driven phenotyping and multivariate genome-wide scanning protocol to a large collection of three-dimensional facial images of individuals with East Asian ancestry (EAS), we identified 244 variants in 166 loci (62 new) associated with typical-range facial variation. A newly proposed polygenic shape analysis indicates that the effects of the variants on facial shape in EAS can be generalized to EUR. Based on this, we further identified 13 variants related to differences between facial shape in EUR and EAS populations. Evolutionary analyses suggest that the difference in nose shape between EUR and EAS populations is caused by a directional selection, due mainly to a local adaptation in Europeans. Our results illustrate the underlying genetic basis for facial differences across populations.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.