ArticleNature communications2022
Reshuffling of the ancestral core-eudicot genome shaped chromatin topology and epigenetic modification in Panax.
Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers.
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62 citing papers in PubMed.
- Polyploidization driven pan-genome structural remodeling and gene duplication mediated functional diversification in Panax.Functional & integrative genomics · 2026Article
- Chromosome-level genome of wild-simulated Panax ginseng identifies SNP markers for germplasm and medicinal quality evaluation.Journal of advanced research · 2026Article
- Comprehensive Identification and Integrated Analysis of theLife (Basel, Switzerland) · 2026Article
- Comprehensive genomic analysis and database construction for Apiales.Journal of advanced research · 2026Article
- Evolution and diversification of PAL-mediated salicylic acid biosynthesis in Rosaceae.Horticulture research · 2026Article
- Single-cell analyses identify the ginseng embryonic protoderm as a native compartment for high-efficiency ginsenoside production.Nature communications · 2026Article
- The Oplopanax elatus genome reveals dammaradienol synthase evolution enabling reconstruction of RK type ginsenosides biosynthesis.Nature communications · 2026Article
- Evolutionary tuning of a biosynthetic gene cluster drives furanocoumarin accumulation and diversification.Nature communications · 2026Article
- Post-polyploid chromosomal diploidization in plants is affected by clade divergence and constrained by shared genomic features.Nature communications · 2026Article
- Autopolyploidization-Induced Chromatin Remodeling Regulates Leaf Size Variation in Brassica rapa.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Identification and characterization of GRAS transcription factors inFrontiers in plant science · 2026Article
- Genome-wide and co-expression network dissection ofFrontiers in plant science · 2026Article
- Metabolomics combined with transcriptomics analysis on ginsenosides accumulation in root of American ginseng plants under foliar applications of brassinolide.Frontiers in plant science · 2026Article
- Comparative mitochondrial genome analysis of Panax ginseng reveals structural variation and genetic diversity.Scientific reports · 2025Article
- Jasmonates mediate increased levels of ginsenosides in Panax Quinquefolius cambial meristematic cell cultures.BMC plant biology · 2025Article
- Conservation and Remodeling of Alternative Splicing Landscapes in the Evolution ofPlants (Basel, Switzerland) · 2025Article
- Telomere-to-telomere genome assembly of yellow-fruited allotetraploid American ginseng (Horticulture research · 2025Article
- Genome-Wide Identification of the AP2/ERF Gene Family and Functional Analysis ofPlants (Basel, Switzerland) · 2025Article
- LGRPv2: A high-value platform for the advancement of Fabaceae genomics.Plant biotechnology journal · 2025Article
- Dynamic Coordination of Alternative Splicing and Subgenome Expression Bias Underlies Rusty Root Symptom Response inPlants (Basel, Switzerland) · 2025Article
2 more citing papers are in PubMed but not listed here.
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12 authors.
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Abstract
All extant core-eudicot plants share a common ancestral genome that has experienced cyclic polyploidizations and (re)diploidizations. Reshuffling of the ancestral core-eudicot genome generates abundant genomic diversity, but the role of this diversity in shaping the hierarchical genome architecture, such as chromatin topology and gene expression, remains poorly understood. Here, we assemble chromosome-level genomes of one diploid and three tetraploid Panax species and conduct in-depth comparative genomic and epigenomic analyses. We show that chromosomal interactions within each duplicated ancestral chromosome largely maintain in extant Panax species, albeit experiencing ca. 100-150 million years of evolution from a shared ancestor. Biased genetic fractionation and epigenetic regulation divergence during polyploidization/(re)diploidization processes generate remarkable biochemical diversity of secondary metabolites in the Panax genus. Our study provides a paleo-polyploidization perspective of how reshuffling of the ancestral core-eudicot genome leads to a highly dynamic genome and to the metabolic diversification of extant eudicot plants.
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