ArticleNature communications2022
NiH-catalysed proximal-selective hydroalkylation of unactivated alkenes and the ligand effects on regioselectivity.
Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Anti-Markovnikov alkene hydroalkylation via iron photocatalysis.Nature catalysis · 2026Article
- Regiocontrolled hydrobromination of unactivated alkenes via direct and chain-walking pathways.Science advances · 2025Article
- Visible-Light-Induced Bond Homolysis in Titanacyclopentadienes for the Catalytic Cyclodimerization of Internal Alkynes.Journal of the American Chemical Society · 2025Article
- Ni-Catalyzed Distal-SelectiveJACS Au · 2025Article
- Catalytic Reductive Annulation Reactions of Alkenes Using Dihaloalkanes.Tetrahedron letters · 2025Article
- Regiodivergent Interrupted Ni-Catalyzed Chain-Walking of Unsaturated Alcohol Side-Chains via Traceless Activating Groups.Journal of the American Chemical Society · 2025Article
- Ni-catalysed remote C(spNature reviews. Chemistry · 2024Review
- Regio- and Enantioselective Hydromethylation of 3-Pyrrolines and Glycals Enabled by Cobalt Catalysis.JACS Au · 2024Article
- CoH-catalyzed asymmetric remote hydroalkylation of heterocyclic alkenes: a rapid approach to chiral five-membered S- and O-heterocycles.Chemical science · 2024Article
- A Catalytic Three-Component Aminofluorination of Unactivated Alkenes with Electron-Rich Amino Sources.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Kinetically-Controlled Ni-Catalyzed Direct Carboxylation of Unactivated Secondary Alkyl Bromides without Chain Walking.Journal of the American Chemical Society · 2024Article
- RegiodivergentJACS Au · 2023Review
- Recent Progress in NiH-Catalyzed Linear or Branch Hydrofunctionalization of Terminal or Internal Alkenes.Topics in current chemistry (Cham) · 2023Review
- Native Amides as Enabling Vehicles for Forging spJournal of the American Chemical Society · 2023Article
Corrections and comments
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Authors and funding
5 authors.
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Abstract
Alkene hydrocarbonation reactions have been developed to supplement traditional electrophile-nucleophile cross-coupling reactions. The branch-selective hydroalkylation method applied to a broad range of unactivated alkenes remains challenging. Herein, we report a NiH-catalysed proximal-selective hydroalkylation of unactivated alkenes to access β- or γ-branched alkyl carboxylic acids and β-, γ- or δ-branched alkyl amines. A broad range of alkyl iodides and bromides with different functional groups can be installed with excellent regiocontrol and availability for site-selective late-stage functionalization of biorelevant molecules. Under modified reaction conditions with NiCl
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