Evidence map›Paper›PMID 35393108›Full record

ArticleJACC. Cardiovascular interventions2022

Clinical Outcomes at 1 Year Following Transcatheter Left Atrial Appendage Occlusion in the United States.

Matthew J Price, David Slotwiner, Chengan Du, James V Freeman, Zoltan Turi, Chidambaram Rammohan, Fred M Kusumoto, Clifford Kavinsky, Joseph Akar, Paul D Varosy and 3 more

Abstract read
In one paragraph

Article in JACC. Cardiovascular interventions, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed.

  1. Review
  2. Article
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  9. Observational
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  11. Incidence and predictors of 2-year mortality following percutaneous left atrial appendage occlusion in the EWOLUTION trial.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2024
    Article
  12. Long-term cardiac computed tomography follow-up after left atrial appendage occlusion.EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology · 2024
    Observational
  13. Review
  14. Article
  15. Practical guide on left atrial appendage closure for the non-implanting physician: an international consensus paper.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2024
    Article
  16. Review
  17. Review
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

Matthew J PriceDivision of Cardiovascular Diseases, Scripps Clinic, La Jolla, California, USA. Electronic address: price.matthew@scrippshealth.org.
David SlotwinerDivision of Cardiology, New York Presbyterian Queens, Weill Cornell Medical College, New York, New York, USA.
Chengan DuCenter for Outcomes Research and Evaluation, Yale-New Haven Hospital, New Haven, Connecticut, USA.
James V FreemanCenter for Outcomes Research and Evaluation, Yale-New Haven Hospital, New Haven, Connecticut, USA; Section of Cardiovascular Medicine, Yale University School of Medicine, New Haven, Connecticut, USA.
Zoltan TuriCenter for Structural and Congenital Heart Disease, Hackensack University Medical Center, Hackensack, New Jersey, USA.
Chidambaram RammohanDivision of Cardiovascular Medicine, Palo Alto Medical Foundation, El Camino Hospital, Mountain View, California.
Fred M KusumotoDepartment of Cardiovascular Disease, Mayo Clinic, Jacksonville, Florida, USA.
Clifford KavinskyDivision of Cardiovascular Medicine, Rush University Medical Center, Chicago, Illinois, USA.
Joseph AkarCenter for Outcomes Research and Evaluation, Yale-New Haven Hospital, New Haven, Connecticut, USA; Section of Cardiovascular Medicine, Yale University School of Medicine, New Haven, Connecticut, USA.
Paul D VarosyVA Eastern Colorado Health Care System and University of Colorado, Aurora, Colorado, USA.
Christina KoutrasAmerican College of Cardiology Foundation, Washington, District of Columbia, USA.
Jeptha P CurtisDivision of Cardiology, New York Presbyterian Queens, Weill Cornell Medical College, New York, New York, USA; Center for Outcomes Research and Evaluation, Yale-New Haven Hospital, New Haven, Connecticut, USA.
Frederick A MasoudiAscension Health, St. Louis, Missouri, USA.

Funding

Safety and Effectiveness of Left Atrial Appendage Closure in Atrial Fibrillation (SAFELY-AF)R01HL142765 · NHLBI · YALE UNIVERSITY · PI FREEMAN, JAMES · 2019 to 2022
$2.9M
Safety and Effectiveness of Left Atrial Appendage Closure in Atrial Fibrillation (SAFELY-AF)R56HL142765 · NHLBI · YALE UNIVERSITY · PI FREEMAN, JAMES · 2018 to 2018
$657k
NHLBI NIH HHS R01 HL142765NHLBI NIH HHS R56 HL142765
6 · The paper itself

Abstract

objectivesThe aim of this study was to report 1-year clinical outcomes following commercial transcatheter left atrial appendage occlusion (LAAO) in the United States.

backgroundThe National Cardiovascular Data Registry LAAO Registry was initiated to meet a condition of Medicare coverage and allow the assessment of clinical outcomes. The 1-year rates of thromboembolic events after transcatheter LAAO in such a large cohort of "real-world" patients have not been previously reported.

methodsPatients entered into the National Cardiovascular Data Registry LAAO Registry for a Watchman procedure between January 1, 2016, and December 31, 2018, were included. The primary endpoint was ischemic stroke. Key secondary endpoints included the rate of ischemic stroke or systemic embolism, mortality, and major bleeding. Major bleeding was defined as any bleeding requiring hospitalization, and/or causing a decrease in hemoglobin level > 2g/dL, and/or requiring blood transfusion that was not hemorrhagic stroke. The Kaplan-Meier method was used for 1-year estimates of cumulative event rates.

resultsThe study population consisted of 36,681 patients. The mean age was 76.0 ± 8.1 years, the mean CHA

conclusionsThis study characterizes important outcomes in a national cohort of patients undergoing transcatheter LAAO in the United States. Clinicians and patients can integrate these data in shared decision making when considering this therapy.

Indexed as

Atrial AppendageAtrial FibrillationIschemic StrokeStrokeAgedAged, 80 and overHemorrhageHumansMedicareTreatment OutcomeUnited Statesatrial fibrillationbleedingleft atrial appendagestrokeWatchman

Identifiers

PMID35393108
PMCPMC9116488

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.