Evidence map›Paper›PMID 35393023›Full record

ReviewJournal of the American College of Cardiology2022

Sex-Related Outcomes of Medical, Percutaneous, and Surgical Interventions for Coronary Artery Disease: JACC Focus Seminar 3/7.

Mario Gaudino, Antonino Di Franco, Davide Cao, Gennaro Giustino, C Noel Bairey Merz, Stephen E Fremes, Ajay J Kirtane, Vijay Kunadian, Jennifer S Lawton, Ruth Marie Masterson Creber and 5 more

Open access · greenAbstract readReview
In one paragraph

Review in Journal of the American College of Cardiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 2 pooled it
10.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 2 syntheses or guidelines pooled it, 67 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Outcomes by sex in the International Study of Comparative Health Effectiveness With Medical and Invasive Approaches (ISCHEMIA) trial.EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology · 2024
    Trial
  4. Trial
  5. Rethinking risk: The prognostic power of coronary plaque in young women.American journal of preventive cardiology · 2026
    Article
  6. Article
  7. Review
  8. Sex-Related Differences in the Prevalence and Clinical Outcomes of Moderate-to-Severe Coronary Artery Calcification in Patients Undergoing Percutaneous Coronary Intervention.Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions · 2026
    Observational
  9. Article
  10. Review
  11. Article
  12. Article
  13. How Sex and Race/Ethnicity Influence Interventional Cardiology Outcomes: What Do We Know?Journal of the Society for Cardiovascular Angiography & Interventions · 2026
    Review
  14. Sex-Based Differences in Long-Term Outcomes Following Intravascular Brachytherapy for In-Stent Restenosis.Journal of the Society for Cardiovascular Angiography & Interventions · 2026
    Article
  15. Coronary artery surgery outcome differences by sex.Indian journal of thoracic and cardiovascular surgery · 2026
    Review
  16. Review
  17. Statin Use Among Women and Men Following Coronary Artery Bypass Surgery.Journal of the American Heart Association · 2025
    Article
  18. Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 9 institutions in 4 countries.

Mario GaudinoDepartment of Cardiothoracic Surgery, Weill Cornell Medicine, New York, New York, USA. Electronic address: mfg9004@med.cornell.edu.
Antonino Di FrancoDepartment of Cardiothoracic Surgery, Weill Cornell Medicine, New York, New York, USA.
Davide CaoThe Zena and Michael A. Wiener Cardiovascular Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Gennaro GiustinoThe Zena and Michael A. Wiener Cardiovascular Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
C Noel Bairey MerzBarbra Streisand Women's Heart Center, Cedars-Sinai Heart Institute, Los Angeles, California, USA.
Stephen E FremesDivision of Cardiac Surgery, Schulich Heart Centre, Department of Surgery, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada.
Ajay J KirtaneDepartment of Cardiology, New York-Presbyterian Hospital/Columbia University Irving Medical Center and the Cardiovascular Research Foundation, New York, New York, USA.
Vijay KunadianTranslational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University and Cardiothoracic Centre, Freeman Hospital, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, United Kingdom.
Jennifer S LawtonDivision of Cardiac Surgery, Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Ruth Marie Masterson CreberDepartment of Healthcare Policy and Research, Weill Cornell Medicine, New York, New York, USA.
Sigrid SandnerDepartment of Cardiac Surgery, Medical University of Vienna, Vienna, Austria.
Birgit VogelThe Zena and Michael A. Wiener Cardiovascular Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Brittany A ZwischenbergerDivision of Cardiovascular and Thoracic Surgery, Department of Surgery, Duke University Medical Center, Durham, North Carolina, USA.
George D DangasThe Zena and Michael A. Wiener Cardiovascular Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Roxana MehranThe Zena and Michael A. Wiener Cardiovascular Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Cardiovascular Institute of the South · USCornell University · USCedars-Sinai Smidt Heart Institute · USDuke Medical Center · USJohns Hopkins University · USMedical University of Vienna · ATNewcastle upon Tyne Hospitals NHS Foundation Trust · GBNewYork–Presbyterian Hospital · USSunnybrook Health Science Centre · CA

Funding

Strengthening Healthcare and Research Engagement through Data Sharing: SHARER01NS123639 · NINDS · WEILL MEDICAL COLL OF CORNELL UNIV · PI Mario FL Gaudino, Ruth Marie Masterson Creber · 2021 to 2026
$4.4M
Randomized comparison of the clinical Outcome of single versus Multiple Arterial grafts: Quality of Life (ROMA:QOL)R01HL152021 · NHLBI · WEILL MEDICAL COLL OF CORNELL UNIV · PI GAUDINO, MARIO FL, MASTERSON CREBER, RUTH MARIE · 2020 to 2024
$4.1M
NHLBI NIH HHS R01 HL152021NINDS NIH HHS R01 NS123639
6 · The paper itself

Abstract

Biological and sociocultural differences between men and women are complex and likely account for most of the variations in the epidemiology and treatment outcomes of coronary artery disease (CAD) between the 2 sexes. Worse outcomes in women have been described following both conservative and invasive treatments of CAD. For example, increased levels of residual platelet reactivity during treatment with antiplatelet drugs, higher rates of adverse cardiovascular outcomes following percutaneous coronary revascularization, and higher operative and long-term mortality after coronary bypass surgery have been reported in women compared with in men. Despite the growing recognition of sex-specific determinants of outcomes, representation of women in clinical studies remains low and sex-specific management strategies are generally not provided in guidelines. This review summarizes the current evidence on sex-related differences in patients with CAD, focusing on the differential outcomes following medical therapy, percutaneous coronary interventions, and coronary artery bypass surgery.

Indexed as

Coronary Artery DiseasePercutaneous Coronary InterventionCoronary Artery BypassFemaleHumansMaleRisk FactorsSex FactorsTreatment Outcomecoronary artery diseasesexwomen

Identifiers

PMID35393023
PMCPMC12096526
OpenAlexW4223458853

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.