ArticleVirology journal2022
Human infection with a reassortant swine-origin influenza A(H1N2)v virus in Taiwan, 2021.
Article in Virology journal, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 19 citations in OpenAlex.
- Genome-wide CRISPR screen identifies STK11 as a critical regulator of sialic acid clusters important for influenza A virus attachment.Journal of advanced research · 2026Article
- Animal Models for Swine Influenza Virus Research: Pathology, Viral Dynamics, and Immune Responses.Viruses · 2026Review
- First report of human infection caused by swine-origin influenza A(H1N2)v virus in mainland China: a confirmed case identified through influenza-like illness surveillance, Kunming (Yunnan), 2025.Frontiers in public health · 2026Article
- Genetic characterization of a novel triple-reassortant influenza A (H1N2) virus from pigs, China, 2021.Frontiers in microbiology · 2026Article
- Cases of Interspecies Transmission of Influenza A Virus from Swine to Humans.Veterinary sciences · 2025Review
- Isolation and Characterization of H1 Subtype Swine Influenza Viruses Recently Circulating in China.Viruses · 2025Article
- Single-cell analysis of nasal epithelial cell development in domestic pigs.Veterinary research · 2024Article
- The evolution, pathogenicity and transmissibility of quadruple reassortant H1N2 swine influenza virus in China: A potential threat to public health.Virologica Sinica · 2024Article
- Detection of a reassortant swine H1N2 influenza A virus from pigs in Hong Kong.Virologica Sinica · 2024Article
- Long-Term Epidemiology and Evolution of Swine Influenza Viruses, Vietnam.Emerging infectious diseases · 2023Article
- Species comparison: human and minipig PBMC reactivity under the influence of immunomodulating compoundsFrontiers in immunology · 2023Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundInfluenza A virus infections occur in different species, causing mild-to-severe symptoms that lead to a heavy disease burden. H1N1, H1N2 and H3N2 are major subtypes of swine influenza A viruses in pigs and occasionally infect humans.
methodsA case infected by novel influenza virus was found through laboratory surveillance system for influenza viruses. Clinical specimens were tested by virus culture and/or real-time RT-PCR. The virus was identified and characterized by gene sequencing and phylogenetic analysis.
resultsIn 2021, for the first time in Taiwan, an influenza A(H1N2)v virus was isolated from a 5-year old girl who was suffering from fever, runny nose and cough. The isolated virus was designated A/Taiwan/1/2021(H1N2)v. Full-genome sequencing and phylogenetic analyses revealed that A/Taiwan/1/2021(H1N2)v is a novel reassortant virus containing hemagglutinin (HA) and neuraminidase (NA) gene segments derived from swine influenza A(H1N2) viruses that may have been circulating in Taiwan for decades, and the other 6 internal genes (PB2, PB2, PA, NP, M and NS) are from human A(H1N1)pdm09 viruses.
conclusionNotably, the HA and NA genes of A/Taiwan/1/2021(H1N2)v separately belong to specific clades that are unique for Taiwanese swine and were proposed to be introduced from humans in different time periods. Bidirectional transmission between humans and swine contributes to influenza virus diversity and poses the next pandemic threat.
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