Evidence map›Paper›PMID 35392632›Full record

ReviewJournal of pain research2022

Nociceptors: Their Role in Body's Defenses, Tissue Specific Variations and Anatomical Update.

Vladimir N Nikolenko, Ekaterina M Shelomentseva, Maria M Tsvetkova, Elina I Abdeeva, Dmitriy B Giller, Juliya V Babayeva, Evgeny E Achkasov, Liliya V Gavryushova, Mikhail Y Sinelnikov

Abstract readReview
In one paragraph

Review in Journal of pain research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Article
  5. A neuromorphic robotic electronic skin with active pain and injury perception.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  6. Neuroprotective Pathway Modulation by a NovelInternational journal of molecular sciences · 2025
    Article
  7. Review
  8. Review
  9. Review
  10. Review
  11. Article
  12. Review
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Vladimir N NikolenkoFirst Moscow State Medical University Named After I.M. Sechenov (Sechenov University), Moscow, 119991, Russia.
Ekaterina M ShelomentsevaLomonosov Moscow State University, Moscow, 119991, Russia.ORCID 0000-0002-9675-3693
Maria M TsvetkovaLomonosov Moscow State University, Moscow, 119991, Russia.
Elina I AbdeevaFirst Moscow State Medical University Named After I.M. Sechenov (Sechenov University), Moscow, 119991, Russia.
Dmitriy B GillerFirst Moscow State Medical University Named After I.M. Sechenov (Sechenov University), Moscow, 119991, Russia.ORCID 0000-0003-1946-5193
Juliya V BabayevaFirst Moscow State Medical University Named After I.M. Sechenov (Sechenov University), Moscow, 119991, Russia.
Evgeny E AchkasovFirst Moscow State Medical University Named After I.M. Sechenov (Sechenov University), Moscow, 119991, Russia.
Liliya V GavryushovaSaratov State Medical University, Saratov, Russian Federation.
Mikhail Y SinelnikovFirst Moscow State Medical University Named After I.M. Sechenov (Sechenov University), Moscow, 119991, Russia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The human body is constantly under the influence of numerous pathological factors: both external and internal. These factors can be potentially harmful and are perceived as such with a specialized nervous system subunit: the nociceptive system. The functional unit of the nociceptive system is the nociceptor. Recent studies have shown that nociceptors play a crucial role in maintaining of defensive homeostasis (responsive, immune, behavioral). Nociceptors respond to potentially harmful stimuli within viscera, bones, muscles, skin and specialized sensory organs. They function as complex predictors of harm through formation of pain stimulus. Their function and structures vary within different tissues. This variability reflects the anatomical and pathological peculiarities of varying tissues. Nociceptors play a significant role in adaptive, protective and behavioral reactions. Their functional capabilities and vast spread throughout the body make them the main units of the body's defense system, allowing us to interact with the inner and outer environments.

Indexed as

defensive homeostasisnociceptorspain perceptiontissue specific variability

Identifiers

PMID35392632
PMCPMC8982820

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.