Evidence map›Paper›PMID 35392605›Full record

ArticleFrontiers in cellular and infection microbiology2022

Yan Zeng, Ahmed Fadaak, Nora Alomeir, Tong Tong Wu, Elena Rustchenko, Shuang Qing, Jianhang Bao, Christie Gilbert, Jin Xiao

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06063239 (Probiotics in Special Needs Patients at High Risk for Tooth Decay), which is not on this map. Cited by 34 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed, 2 pooled it
6.4field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06063239 naunknown statusnot on this mapstarted 2023, after this paper: background citation

Probiotics in Special Needs Patients at High Risk for Tooth Decay: a Randomized Controlled Trial.

TypeinterventionalSponsorG. d'Annunzio UniversityRan2023 to 2024Enrolled70ConditionsTooth Decay, Intellectual Disability, Caries,DentalArmsTest Group, Positive Control, Negative Control
3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 2 syntheses or guidelines pooled it, 42 citations in OpenAlex.

  1. Pooled it
  2. Unveiling the dual nature ofFrontiers in oral health · 2025
    Pooled it
  3. Review
  4. Probiotic and Postbiotic Interactions ofAntibiotics (Basel, Switzerland) · 2026
    Article
  5. Capsaicin inhibits cariogenicJournal of oral microbiology · 2026
    Article
  6. Effect ofAmerican journal of translational research · 2026
    Article
  7. [Machine learning-based prediction model for caries in the first molars of 9-year-old children in Suzhou].Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology · 2025
    Article
  8. Article
  9. Effect ofJournal of dental research · 2025
    Article
  10. Engineered Tissue Models to Decode Host-Microbiota Interactions.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Review
  11. Metabolic modulation and multi-species interaction:Frontiers in cellular and infection microbiology · 2025
    Article
  12. Article
  13. Effects ofFoods (Basel, Switzerland) · 2024
    Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Differential alteration inMicrobiology spectrum · 2024
    Article
  19. Unveiling the complexity of early childhood caries:Journal of oral microbiology · 2024
    Review
  20. The role ofJournal of oral microbiology · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Yan ZengEastman Institute for Oral Health, University of Rochester Medical Center, Rochester, NY, United States.
Ahmed FadaakEastman Institute for Oral Health, University of Rochester Medical Center, Rochester, NY, United States.
Nora AlomeirEastman Institute for Oral Health, University of Rochester Medical Center, Rochester, NY, United States.
Tong Tong WuDepartment of Biostatistics and Computational Biology, University of Rochester Medical Center, Rochester, NY, United States.
Elena RustchenkoDepartment of Biochemistry and Biophysics, University of Rochester Medical Center, Rochester, NY, United States.
Shuang QingUniversity of Rochester River Campus, Rochester, NY, United States.
Jianhang BaoEastman Institute for Oral Health, University of Rochester Medical Center, Rochester, NY, United States.
Christie GilbertMicrobiology and Immunology, University of Rochester Medical Center, Rochester, NY, United States.
Jin XiaoEastman Institute for Oral Health, University of Rochester Medical Center, Rochester, NY, United States.
University of Rochester Medical Center · USEastman Chemical Company (United States) · USUniversity of Rochester · US

Funding

Association between Oral Candida albicans and the Onset of Severe Early Childhood CariesK23DE027412 · NIDCR · UNIVERSITY OF ROCHESTER · PI XIAO, JIN · 2018 to 2022
$748k
NIDCR NIH HHS K23 DE027412
6 · The paper itself

Abstract

Dental caries, an ecological dysbiosis of oral microflora, initiates from the virulent biofilms formed on tooth surfaces where cariogenic microorganisms metabolize dietary carbohydrates, producing acid that demineralizes tooth enamel. Forming cariogenic biofilms,

Indexed as

Dental CariesLactiplantibacillus plantarumBiofilmsCandida albicansStreptococcus mutansCandida albicanscross-kingdom interactionsdental cariesLactobacillus plantarummultispecies biofilmsStreptococcus mutans

Identifiers

PMID35392605
PMCPMC8980721
OpenAlexW4220655216

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.