Evidence map›Paper›PMID 35392493›Full record

ArticleDisease markers2022

Circulating ADAMTS13 Levels Are Associated with an Increased Occurrence of Obstructive Sleep Apnea.

Mengling Huang, Sheng Liu, Shuang Liu, Wanwan Wen, Yu Ning, Yifan Jia, Yunxiao Yang, Xiaolu Jiao, Weiping Zheng, Ming Zhang

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Disease markers, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.1field-weighted citation impact, top 63% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Mengling HuangDepartment of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.
Sheng LiuDepartment of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.
Shuang LiuKey Laboratory of Upper Airway Dysfunction-Related Cardiovascular Diseases, Beijing Anzhen Hospital, Capital Medical University, Beijing Institute of Heart, Lung, And Blood Vessel Diseases, Beijing 100029, China.
Wanwan WenDepartment of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.ORCID https://orcid.org/0000-0003-4343-4733
Yu NingDepartment of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.
Yifan JiaDepartment of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.ORCID https://orcid.org/0000-0003-2599-7161
Yunxiao YangDepartment of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.ORCID https://orcid.org/0000-0001-7921-2484
Xiaolu JiaoKey Laboratory of Remodeling-Related Cardiovascular Diseases, Beijing Anzhen Hospital, Capital Medical University, Beijing Institute of Heart, Lung and Blood Vessel Diseases, Beijing 100029, China.
Weiping ZhengDepartment of Cardiology, Shengli Clinical Medical College of Fujian Medical University, 134 East Street, Fuzhou, 350001 Fujian Province, China.ORCID https://orcid.org/0000-0002-6072-5199
Ming ZhangDepartment of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.ORCID https://orcid.org/0000-0002-3752-0734
Capital Medical University · CNFujian Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background and Aims: Obstructive sleep apnea (OSA) is strongly associated with obesity, metabolic diseases, coronary artery disease (CAD), stroke, hypertension, and other disorders. This study assessed the relationship between circulating a disintegrin and metalloprotease with a thrombospondin type 1 motif, member 13 (ADAMTS13) levels and the presence of OSA. Materials and Methods: This cross-sectional study included a total of 223 patients. We used a powerful high-throughput multiplexed immunobead-based assay to detect circulating levels of ADAMTS13. The associations between circulating ADAMTS13 levels and OSA were evaluated by multivariate logistic regression analysis. Results: Circulating ADAMTS13 levels were significantly elevated in patients with OSA compared with controls (0.8 vs. 2.7 Conclusion: Circulating ADAMTS13 levels were significantly correlated with the presence of OSA. ADAMTS13 may therefore function as a novel biomarker for monitoring the development and progression of OSA.

Indexed as

ADAMTS13 ProteinCoronary Artery DiseaseSleep Apnea, ObstructiveBiomarkersCross-Sectional StudiesHumansOdds RatioRisk FactorsADAMTS13 ProteinADAMTS13 protein, humanBiomarkers

Identifiers

PMID35392493
PMCPMC8983172
OpenAlexW4220851538

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.